{
    "disease_id": "DOID:0060076",
    "recommended_name": {
        "id": "DOID:0060076",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060076",
        "name": "estrogen-receptor negative breast cancer",
        "description": "A breast cancer that is characterized by the absence of estrogen receptors."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0060076"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060076",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060076",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q9DCN2-1",
            "uniprot_ac": "Q9DCN2",
            "uniprot_id": "NB5R3_MOUSE",
            "refseq_ac": "NP_084063",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "NADH-cytochrome b5 reductase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "B5R",
                    "type": "synonym"
                },
                {
                    "name": "Cytochrome b5 reductase",
                    "type": "synonym"
                },
                {
                    "name": "Diaphorase-1",
                    "type": "synonym"
                },
                {
                    "name": "NADH-cytochrome b5 reductase 3",
                    "type": "synonym"
                },
                {
                    "name": "diaphorase 1 (NADH)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cyb5r3",
                    "type": "recommended"
                },
                {
                    "name": "0610016L08Rik",
                    "type": "synonym"
                },
                {
                    "name": "2500002N19Rik",
                    "type": "synonym"
                },
                {
                    "name": "B5R",
                    "type": "synonym"
                },
                {
                    "name": "Cyb5r3",
                    "type": "synonym"
                },
                {
                    "name": "Dia-1",
                    "type": "synonym"
                },
                {
                    "name": "Dia1",
                    "type": "synonym"
                },
                {
                    "name": "WU:Cyb5r3",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
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            "uniprot_ac": "P38626",
            "uniprot_id": "NCB5R_YEAST",
            "refseq_ac": "NP_012221",
            "glycoprotein": "no",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
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                {
                    "name": "NADH-cytochrome b5 reductase 1",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "Microsomal cytochrome b reductase",
                    "type": "synonym"
                },
                {
                    "name": "P35",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome-b5 reductase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CBR1",
                    "type": "recommended"
                },
                {
                    "name": "CBR1",
                    "type": "synonym"
                },
                {
                    "name": "CBR5",
                    "type": "synonym"
                },
                {
                    "name": "CBR",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q12746-1",
            "uniprot_ac": "Q12746",
            "uniprot_id": "PGA3_YEAST",
            "refseq_ac": "NP_013581",
            "glycoprotein": "no",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
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                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
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                {
                    "name": "Plasma membrane-associated coenzyme Q6 reductase PGA3",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "Processing of GAS1 and ALP protein 3",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome-b5 reductase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PGA3",
                    "type": "recommended"
                },
                {
                    "name": "NQR1",
                    "type": "synonym"
                },
                {
                    "name": "PGA3",
                    "type": "synonym"
                },
                {
                    "name": "YM4987.10C",
                    "type": "synonym"
                },
                {
                    "name": "YM7056.01C",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q04516-1",
            "uniprot_ac": "Q04516",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
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                }
            ],
            "protein_names": [
                {
                    "name": "Uncharacterized oxidoreductase AIM33",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "Altered inheritance of mitochondria protein 33",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome-b5 reductase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "AIM33",
                    "type": "recommended"
                },
                {
                    "name": "AIM33",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20070-1",
            "uniprot_ac": "P20070",
            "uniprot_id": "NB5R3_RAT",
            "refseq_ac": "NP_620232",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "NADH-cytochrome b5 reductase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "B5R",
                    "type": "synonym"
                },
                {
                    "name": "Cytochrome b5 reductase",
                    "type": "synonym"
                },
                {
                    "name": "Diaphorase (NADH) (cytochrome b-5 reductase)",
                    "type": "synonym"
                },
                {
                    "name": "Diaphorase-1",
                    "type": "synonym"
                },
                {
                    "name": "NADH-cytochrome b5 reductase 3",
                    "type": "synonym"
                },
                {
                    "name": "diaphorase-1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cyb5r3",
                    "type": "recommended"
                },
                {
                    "name": "Cyb5r3",
                    "type": "synonym"
                },
                {
                    "name": "Dia1",
                    "type": "synonym"
                },
                {
                    "name": "Nadhcb5",
                    "type": "synonym"
                },
                {
                    "name": "RNNADHCB5",
                    "type": "synonym"
                }
            ],
            "record_id": "P20070-1",
            "evidence": [
                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P12843-1",
            "uniprot_ac": "P12843",
            "uniprot_id": "IBP2_RAT",
            "refseq_ac": "NP_037254",
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            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Insulin-like growth factor-binding protein 2",
                    "type": "recommended"
                },
                {
                    "name": "BRL-BP",
                    "type": "synonym"
                },
                {
                    "name": "IBP-2",
                    "type": "synonym"
                },
                {
                    "name": "IGF-binding protein 2",
                    "type": "synonym"
                },
                {
                    "name": "IGFBP-2",
                    "type": "synonym"
                },
                {
                    "name": "insulin-like growth factor-binding protein 2 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Igfbp2",
                    "type": "recommended"
                },
                {
                    "name": "BRL-BP",
                    "type": "synonym"
                },
                {
                    "name": "IBP-2",
                    "type": "synonym"
                },
                {
                    "name": "IGFBP-2",
                    "type": "synonym"
                },
                {
                    "name": "ILGFBPA",
                    "type": "synonym"
                },
                {
                    "name": "Igfbp-2",
                    "type": "synonym"
                },
                {
                    "name": "Igfbp2",
                    "type": "synonym"
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            ],
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                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "X2JGK6-1",
            "uniprot_ac": "X2JGK6",
            "uniprot_id": "X2JGK6_DROME",
            "refseq_ac": "NP_001287035",
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            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "NADH-cytochrome b5 reductase",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "CG5946-PG",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein, isoform G",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG5946",
                    "type": "recommended"
                },
                {
                    "name": "CG5946",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5946",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5946",
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            ],
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                {
                    "id": "0060076",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P00387-1",
            "uniprot_ac": "P00387",
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            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "NADH-cytochrome b5 reductase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "B5R",
                    "type": "synonym"
                },
                {
                    "name": "Cytochrome b5 reductase",
                    "type": "synonym"
                },
                {
                    "name": "Diaphorase-1",
                    "type": "synonym"
                },
                {
                    "name": "NADH-cytochrome b5 reductase 3 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "NADH-cytochrome b5 reductase 3 membrane-bound form",
                    "type": "synonym"
                },
                {
                    "name": "NADH-cytochrome b5 reductase 3 soluble form",
                    "type": "synonym"
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                {
                    "name": "diaphorase-1",
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                },
                {
                    "name": "mutant NADH-cytochrome b5 reductase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CYB5R3",
                    "type": "recommended"
                },
                {
                    "name": "B5R",
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                },
                {
                    "name": "CYB5R3",
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                },
                {
                    "name": "DIA1",
                    "type": "synonym"
                }
            ],
            "record_id": "P00387-1",
            "evidence": [
                {
                    "id": "0060076",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060076"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060076"
}