{
    "disease_id": "DOID:0051054",
    "recommended_name": {
        "id": "DOID:0051054",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0051054",
        "name": "coarctation of the aorta",
        "description": "A congenital heart disease that is characterized by the luminal narrowing of the thoracic aortic arch, typically located just beyond the left subclavian artery. This narrowing creates an obstruction that can lead to significant cardiovascular complications, including systemic hypertension, left ventricular hypertrophy, and eventually heart failure."
    },
    "synonyms": [
        {
            "id": "MONDO:0007345",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007345",
            "name": "aorta coarctation",
            "description": "Congenital narrowing of a segment of the aorta. Signs and symptoms include hypertension, muscle weakness, shortness of breath, headaches and leg cramps."
        },
        {
            "id": "MONDO:0007345",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007345",
            "name": "aortic coarctation",
            "description": ""
        },
        {
            "id": "MONDO:0007345",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007345",
            "name": "coarctation of the aorta",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0051054"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0051054",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0051054",
            "categories": []
        },
        {
            "id": "MONDO:0007345",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007345",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "B0V153-1",
            "uniprot_ac": "B0V153",
            "uniprot_id": "B0V153_DANRE",
            "refseq_ac": "NP_001121727",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Methylenetetrahydrofolate reductase (NADPH)",
                    "type": "recommended"
                },
                {
                    "name": "1.5.1.53",
                    "type": "synonym"
                },
                {
                    "name": "5,10-methylenetetrahydrofolate reductase (NADPH)",
                    "type": "synonym"
                },
                {
                    "name": "methylenetetrahydrofolate reductase (NADPH)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mthfr",
                    "type": "recommended"
                },
                {
                    "name": "fa92h12",
                    "type": "synonym"
                },
                {
                    "name": "im:7144504",
                    "type": "synonym"
                },
                {
                    "name": "mthfr",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-100a1.4",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa92h12",
                    "type": "synonym"
                }
            ],
            "record_id": "B0V153-1",
            "evidence": [
                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P11859-1",
            "uniprot_ac": "P11859",
            "uniprot_id": "ANGT_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Angiotensinogen",
                    "type": "recommended"
                },
                {
                    "name": "Ang III",
                    "type": "synonym"
                },
                {
                    "name": "Ang II",
                    "type": "synonym"
                },
                {
                    "name": "Ang IV",
                    "type": "synonym"
                },
                {
                    "name": "Ang I",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin 1-10",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin 1-8",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin 2-8",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin 3-8",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin III",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin II",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin IV",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin I",
                    "type": "synonym"
                },
                {
                    "name": "Des-Asp[1]-angiotensin II",
                    "type": "synonym"
                },
                {
                    "name": "Serpin A8",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Agt",
                    "type": "recommended"
                },
                {
                    "name": "Serpina8",
                    "type": "synonym"
                }
            ],
            "record_id": "P11859-1",
            "evidence": [
                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9WU20-1",
            "uniprot_ac": "Q9WU20",
            "uniprot_id": "MTHR_MOUSE",
            "refseq_ac": "NP_034970",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Methylenetetrahydrofolate reductase (NADPH)",
                    "type": "recommended"
                },
                {
                    "name": "1.5.1.53",
                    "type": "synonym"
                },
                {
                    "name": "5,10-methylenetetrahydrofolate reductase",
                    "type": "synonym"
                },
                {
                    "name": "methylenetetrahydrofolate reductase (NADPH) isoform b",
                    "type": "synonym"
                },
                {
                    "name": "methylenetetrahydrofolate reductase (NADPH)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mthfr",
                    "type": "recommended"
                },
                {
                    "name": "Mthfr",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9WU20-1",
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P09470-1",
            "uniprot_ac": "P09470",
            "uniprot_id": "ACE_MOUSE",
            "refseq_ac": "NP_033728",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Angiotensin-converting enzyme",
                    "type": "recommended"
                },
                {
                    "name": "3.4.15.1",
                    "type": "synonym"
                },
                {
                    "name": "ACE",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl carboxypeptidase I",
                    "type": "synonym"
                },
                {
                    "name": "Kininase II",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin I converting enzyme (peptidyl-dipeptidase A) 1",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin-converting enzyme isoform 2 precursor",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin-converting enzyme",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl carboxypeptidase I",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl peptidase",
                    "type": "synonym"
                },
                {
                    "name": "kininase II",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ace",
                    "type": "recommended"
                },
                {
                    "name": "Ace",
                    "type": "synonym"
                },
                {
                    "name": "CD143",
                    "type": "synonym"
                },
                {
                    "name": "Dcp1",
                    "type": "synonym"
                }
            ],
            "record_id": "P09470-1",
            "evidence": [
                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P46151-1",
            "uniprot_ac": "P46151",
            "uniprot_id": "MTHR1_YEAST",
            "refseq_ac": "NP_015302",
            "glycoprotein": "no",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Methylenetetrahydrofolate reductase 1",
                    "type": "recommended"
                },
                {
                    "name": "1.5.1.20",
                    "type": "synonym"
                },
                {
                    "name": "methylenetetrahydrofolate reductase (NAD(P)H) MET12",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MET12",
                    "type": "recommended"
                },
                {
                    "name": "LPB8C",
                    "type": "synonym"
                },
                {
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            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
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        },
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            "uniprot_canonical_ac": "P53128-1",
            "uniprot_ac": "P53128",
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                    "name": "Saccharomyces cerevisiae S288C",
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                }
            ],
            "protein_names": [
                {
                    "name": "Methylenetetrahydrofolate reductase 2",
                    "type": "recommended"
                },
                {
                    "name": "1.5.1.53",
                    "type": "synonym"
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                {
                    "name": "YmL45",
                    "type": "synonym"
                },
                {
                    "name": "methylenetetrahydrofolate reductase (NAD(P)H) MET13",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "MET13",
                    "type": "recommended"
                },
                {
                    "name": "G2882",
                    "type": "synonym"
                },
                {
                    "name": "MET11",
                    "type": "synonym"
                },
                {
                    "name": "MET13",
                    "type": "synonym"
                },
                {
                    "name": "MRPL45",
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                }
            ],
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                    "id": "0051054",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
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            ]
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                },
                {
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                {
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                {
                    "name": "Dipeptidyl carboxypeptidase I",
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                {
                    "name": "Kininase II",
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                {
                    "name": "angiotensin 1 converting enzyme 1",
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                {
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                {
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                {
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                    "name": "angiotensin-converting enzyme",
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                    "name": "dipeptidyl carboxypeptidase I",
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                    "id": "0051054",
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                }
            ],
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                    "name": "Angiotensinogen",
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                {
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                {
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                {
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                },
                {
                    "name": "Angiotensin 1-10",
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                {
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                {
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                {
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                },
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                {
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                },
                {
                    "name": "Angiotensin IV",
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                {
                    "name": "Angiotensin I",
                    "type": "synonym"
                },
                {
                    "name": "Des-Asp[1]-angiotensin II",
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                },
                {
                    "name": "Serpin A8",
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                {
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                {
                    "name": "angiotensinogen (serpin peptidase inhibitor, clade A, member 8)",
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                    "name": "AngII",
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                {
                    "name": "Ang",
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                {
                    "name": "PAT",
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                    "id": "0051054",
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            "uniprot_ac": "A0A8I6A4C5",
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                    "name": "Rattus norvegicus",
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                }
            ],
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                    "name": "Methylenetetrahydrofolate reductase",
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                {
                    "name": "methylenetetrahydrofolate reductase (NADPH) isoform X2",
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            ],
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                }
            ],
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                    "name": "Glutaminase kidney isoform, mitochondrial",
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                },
                {
                    "name": "GLS",
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                },
                {
                    "name": "K-glutaminase",
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                },
                {
                    "name": "L-glutamine amidohydrolase",
                    "type": "synonym"
                },
                {
                    "name": "glutaminase kidney isoform, mitochondrial isoform a",
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                {
                    "name": "kidney-type glutaminase",
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                    "id": "0051054",
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            "uniprot_ac": "Q9VLZ8",
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            "refseq_ac": "NP_001260209",
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            "species": [
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                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
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                }
            ],
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                    "name": "CG6717-PB",
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                    "name": "Serpin 28B, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28B, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Spn28B-PB",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 7",
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                },
                {
                    "name": "serpin 28B, isoform B",
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                }
            ],
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                    "name": "Spn28B",
                    "type": "recommended"
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                {
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                {
                    "name": "Dmel_CG6717",
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                {
                    "name": "Spn28B",
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                },
                {
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                {
                    "id": "0051054",
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                }
            ]
        },
        {
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            "uniprot_ac": "Q9VII7",
            "uniprot_id": "Q9VII7_DROME",
            "refseq_ac": "NP_524956",
            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG9334-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 38F, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Spn38F-PA",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 3",
                    "type": "synonym"
                },
                {
                    "name": "serpin 38F, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "serpin 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn38F",
                    "type": "recommended"
                },
                {
                    "name": "CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Sp3",
                    "type": "synonym"
                },
                {
                    "name": "Spn38F",
                    "type": "synonym"
                },
                {
                    "name": "Spn3",
                    "type": "synonym"
                },
                {
                    "name": "sp3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VII7-1",
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VFC1-1",
            "uniprot_ac": "Q9VFC1",
            "uniprot_id": "Q9VFC1_DROME",
            "refseq_ac": "NP_650427",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG6687-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dm-serpin-88Eb",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 88Eb",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Eb-PA",
                    "type": "synonym"
                },
                {
                    "name": "serpin 88Eb",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn88Eb",
                    "type": "recommended"
                },
                {
                    "name": "CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Spn88EB",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Eb",
                    "type": "synonym"
                },
                {
                    "name": "serpin",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VFC1-1",
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLQ7-1",
            "uniprot_ac": "Q9VLQ7",
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "CG8137-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28F",
                    "type": "synonym"
                },
                {
                    "name": "Spn28F-PA",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 2",
                    "type": "synonym"
                },
                {
                    "name": "serpin 28F",
                    "type": "synonym"
                },
                {
                    "name": "serpin 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn28F",
                    "type": "recommended"
                },
                {
                    "name": "CG8137",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8137",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8137",
                    "type": "synonym"
                },
                {
                    "name": "Sp2",
                    "type": "synonym"
                },
                {
                    "name": "Spn28F",
                    "type": "synonym"
                },
                {
                    "name": "Spn2",
                    "type": "synonym"
                },
                {
                    "name": "sp2",
                    "type": "synonym"
                },
                {
                    "name": "spn2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VLQ7-1",
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VFC2-1",
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            "uniprot_id": "SP88E_DROME",
            "refseq_ac": "NP_524954",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serine protease inhibitor 88Ea",
                    "type": "recommended"
                },
                {
                    "name": "CG18525-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dm-serpin-88Ea",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 88Ea",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Ea-PA",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 5",
                    "type": "synonym"
                },
                {
                    "name": "serpin 5",
                    "type": "synonym"
                },
                {
                    "name": "serpin 88Ea, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "serpin5",
                    "type": "synonym"
                },
                {
                    "name": "serpin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn88Ea",
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                },
                {
                    "name": "CG18525",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG18525",
                    "type": "synonym"
                },
                {
                    "name": "Sp5",
                    "type": "synonym"
                },
                {
                    "name": "Spn5",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Ea",
                    "type": "synonym"
                },
                {
                    "name": "sp5",
                    "type": "synonym"
                },
                {
                    "name": "spn5",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VL44-1",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG4804-PA",
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                },
                {
                    "name": "Serpin 31A",
                    "type": "synonym"
                },
                {
                    "name": "Spn31A-PA",
                    "type": "synonym"
                },
                {
                    "name": "serpin 31A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn31A",
                    "type": "recommended"
                },
                {
                    "name": "CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Spn31A",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q0E8V6-1",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG31902-PB",
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                },
                {
                    "name": "Serpin 28Da",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Da-PB",
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                },
                {
                    "name": "serpin 28Da",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn28Da",
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                {
                    "name": "CG12318",
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                },
                {
                    "name": "CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Da",
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                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLV3-1",
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            "uniprot_id": "Q9VLV3_DROME",
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                {
                    "name": "Drosophila melanogaster",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG33121-PB",
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                },
                {
                    "name": "Serpin 28Db",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Db-PB",
                    "type": "synonym"
                },
                {
                    "name": "serpin 28Db",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn28Db",
                    "type": "recommended"
                },
                {
                    "name": "CG12318",
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                },
                {
                    "name": "CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Db",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9V3N1-1",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Serine protease inhibitor 27A",
                    "type": "recommended"
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                {
                    "name": "CG11331-PB",
                    "type": "synonym"
                },
                {
                    "name": "Dm-serpin-27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin-27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin27A",
                    "type": "synonym"
                },
                {
                    "name": "Spn27A-PB",
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                },
                {
                    "name": "serpin 27A, isoform B",
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                },
                {
                    "name": "serpin 27A",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn27A",
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                },
                {
                    "name": "CG11331",
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                },
                {
                    "name": "Dm-Spn27A",
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                },
                {
                    "name": "Dmel\\CG11331",
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                },
                {
                    "name": "EST1",
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                },
                {
                    "name": "Sp27A",
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                },
                {
                    "name": "Spn27A",
                    "type": "synonym"
                },
                {
                    "name": "Spn27a",
                    "type": "synonym"
                },
                {
                    "name": "Spn27",
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                },
                {
                    "name": "sp27A",
                    "type": "synonym"
                },
                {
                    "name": "spn27A",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q7YTY6-1",
            "uniprot_ac": "Q7YTY6",
            "uniprot_id": "SP42D_DROME",
            "refseq_ac": "NP_001163067",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Serine protease inhibitor 42Dd",
                    "type": "recommended"
                },
                {
                    "name": "CG9456-PB",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 42Dd",
                    "type": "synonym"
                },
                {
                    "name": "Spn42Dd-PB",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 1",
                    "type": "synonym"
                },
                {
                    "name": "serpin 1",
                    "type": "synonym"
                },
                {
                    "name": "serpin 42Dd",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn42Dd",
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                },
                {
                    "name": "CG9456",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9456",
                    "type": "synonym"
                },
                {
                    "name": "Spn1",
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                },
                {
                    "name": "Spn42Dd",
                    "type": "synonym"
                },
                {
                    "name": "sp1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7YTY6-1",
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VTI0-1",
            "uniprot_ac": "Q9VTI0",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Methylenetetrahydrofolate reductase-like catalytic domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "CG7560-PA",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG7560",
                    "type": "recommended"
                },
                {
                    "name": "BEST:GH18008",
                    "type": "synonym"
                },
                {
                    "name": "CG7560",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG7560",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG7560",
                    "type": "synonym"
                },
                {
                    "name": "gh18008",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLJ6-1",
            "uniprot_ac": "Q9VLJ6",
            "uniprot_id": "ACER_DROME",
            "refseq_ac": "NP_001260258",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Angiotensin-converting enzyme-related protein",
                    "type": "recommended"
                },
                {
                    "name": "3.4.15.1",
                    "type": "synonym"
                },
                {
                    "name": "Acer-PB",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin-converting enzyme peptidase",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin-converting enzyme-related, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "CG10593-PB",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin-converting enzyme-related",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Acer",
                    "type": "recommended"
                },
                {
                    "name": "ACER",
                    "type": "synonym"
                },
                {
                    "name": "ACE",
                    "type": "synonym"
                },
                {
                    "name": "Acer",
                    "type": "synonym"
                },
                {
                    "name": "CG10593",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG10593",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG10593",
                    "type": "synonym"
                },
                {
                    "name": "acer",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k07704",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VLJ6-1",
            "evidence": [
                {
                    "id": "0051054",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0051054"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q10714-1",
            "uniprot_ac": "Q10714",
            "uniprot_id": "ACE_DROME",
            "refseq_ac": "NP_001285915",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Angiotensin-converting enzyme",
                    "type": "recommended"
                },
                {
                    "name": "3.4.15.1",
                    "type": "synonym"
                },
                {
                    "name": "Ance-PC",
                    "type": "synonym"
                },
                {
                    "name": "CG8827-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl carboxypeptidase I",
                    "type": "synonym"
                },
                {
                    "name": "Kininase II",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin I-converting enzyme",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin converting enzyme, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin-converting enzyme",
                    "type": "synonym"
                },
                {
                    "name": "anon-fast-evolving-3D10",
                    "type": "synonym"
                },
                {
                    "name": "race",
                    "type": "synonym"
                },
                {
                    "name": "related to angiotensin converting enzyme",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ance",
                    "type": "recommended"
                },
                {
                    "name": "ACE",
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                },
                {
                    "name": "ANCE",
                    "type": "synonym"
                },
                {
                    "name": "AnCE",
                    "type": "synonym"
                },
                {
                    "name": "Ance",
                    "type": "synonym"
                },
                {
                    "name": "BG:DS08220.3",
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                },
                {
                    "name": "CG8827",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8827",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8827",
                    "type": "synonym"
                },
                {
                    "name": "RACE",
                    "type": "synonym"
                },
                {
                    "name": "Race",
                    "type": "synonym"
                },
                {
                    "name": "ance",
                    "type": "synonym"
                },
                {
                    "name": "anon-EST:fe3D10",
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                },
                {
                    "name": "race",
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                }
            ],
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            ]
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            ],
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                {
                    "name": "Dual specificity protein kinase CLK2",
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                },
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                    "name": "2.7.12.1",
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                },
                {
                    "name": "CDC-like kinase 2",
                    "type": "synonym"
                },
                {
                    "name": "CLK kinase",
                    "type": "synonym"
                },
                {
                    "name": "dual specificity protein kinase CLK2 isoform 1",
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                },
                {
                    "name": "dual specificity protein kinase CLK2",
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                }
            ],
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                    "name": "CLK2",
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                    "name": "CLK2",
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            ],
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                    "name": "Angiotensin-converting enzyme",
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                {
                    "name": "3.4.15.1",
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                },
                {
                    "name": "ACE",
                    "type": "synonym"
                },
                {
                    "name": "CD143 antigen",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl carboxypeptidase I",
                    "type": "synonym"
                },
                {
                    "name": "Kininase II",
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                },
                {
                    "name": "angiotensin I converting enzyme (peptidyl-dipeptidase A) 1",
                    "type": "synonym"
                },
                {
                    "name": "angiotensin-converting enzyme isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "carboxycathepsin",
                    "type": "synonym"
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                {
                    "name": "dipeptidyl carboxypeptidase 1",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl carboxypeptidase I",
                    "type": "synonym"
                },
                {
                    "name": "kininase II",
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                {
                    "name": "peptidase P",
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                }
            ],
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                    "name": "ACE",
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                {
                    "name": "ACE1",
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                },
                {
                    "name": "ACE",
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                },
                {
                    "name": "CD143",
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                },
                {
                    "name": "DCP1",
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                },
                {
                    "name": "DCP",
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                    "id": "0051054",
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                }
            ],
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                    "name": "Methylenetetrahydrofolate reductase (NADPH)",
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                    "name": "1.5.1.53",
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                },
                {
                    "name": "5,10-methylenetetrahydrofolate reductase (NADPH)",
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                },
                {
                    "name": "methylenetetrahydrofolate reductase (NAD(P)H)",
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                },
                {
                    "name": "methylenetetrahydrofolate reductase (NADPH) isoform 1",
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                }
            ],
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                    "name": "MTHFR",
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                    "name": "MTHFR",
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                }
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                    "id": "0051054",
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                }
            ],
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                    "name": "Angiotensinogen",
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                {
                    "name": "Ang III",
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                    "name": "Ang II",
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                {
                    "name": "Ang IV",
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                {
                    "name": "Ang I",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin 1-10",
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                },
                {
                    "name": "Angiotensin 1-8",
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                },
                {
                    "name": "Angiotensin 2-8",
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                },
                {
                    "name": "Angiotensin 3-8",
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                {
                    "name": "Angiotensin III",
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                {
                    "name": "Angiotensin II",
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                },
                {
                    "name": "Angiotensin IV",
                    "type": "synonym"
                },
                {
                    "name": "Angiotensin I",
                    "type": "synonym"
                },
                {
                    "name": "Des-Asp[1]-angiotensin II",
                    "type": "synonym"
                },
                {
                    "name": "Serpin A8",
                    "type": "synonym"
                },
                {
                    "name": "alpha-1 antiproteinase, antitrypsin",
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                },
                {
                    "name": "angiotensin II",
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                },
                {
                    "name": "angiotensinogen precursor",
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                },
                {
                    "name": "fetal-liver predominant transporter 1",
                    "type": "synonym"
                },
                {
                    "name": "pre-angiotensinogen",
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                },
                {
                    "name": "serine (or cysteine) proteinase inhibitor",
                    "type": "synonym"
                },
                {
                    "name": "serpin A8",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade A, member 8",
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            ],
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                    "name": "AGT",
                    "type": "recommended"
                },
                {
                    "name": "AGT",
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                },
                {
                    "name": "ANHU",
                    "type": "synonym"
                },
                {
                    "name": "SERPINA8",
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                },
                {
                    "name": "hFLT1",
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                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0051054"
}