{
    "disease_id": "DOID:0050804",
    "recommended_name": {
        "id": "DOID:0050804",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050804",
        "name": "glioblastoma proneural subtype",
        "description": "A glioblastoma that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0050804"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050804",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050804",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P13405-1",
            "uniprot_ac": "P13405",
            "uniprot_id": "RB_MOUSE",
            "refseq_ac": "NP_033055",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Retinoblastoma-associated protein",
                    "type": "recommended"
                },
                {
                    "name": "Rb",
                    "type": "synonym"
                },
                {
                    "name": "p110-RB1",
                    "type": "synonym"
                },
                {
                    "name": "pRb",
                    "type": "synonym"
                },
                {
                    "name": "pp105",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rb1",
                    "type": "recommended"
                },
                {
                    "name": "Rb-1",
                    "type": "synonym"
                },
                {
                    "name": "Rb1",
                    "type": "synonym"
                },
                {
                    "name": "Rb",
                    "type": "synonym"
                },
                {
                    "name": "p110-RB1",
                    "type": "synonym"
                },
                {
                    "name": "pRb",
                    "type": "synonym"
                },
                {
                    "name": "pp105",
                    "type": "synonym"
                }
            ],
            "record_id": "P13405-1",
            "evidence": [
                {
                    "id": "0050804",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050804"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33568-1",
            "uniprot_ac": "P33568",
            "uniprot_id": "RB_RAT",
            "refseq_ac": "NP_058741",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Retinoblastoma-associated protein",
                    "type": "recommended"
                },
                {
                    "name": "Rb",
                    "type": "synonym"
                },
                {
                    "name": "Retinoblastoma 1 (including osteosarcoma)",
                    "type": "synonym"
                },
                {
                    "name": "pRb",
                    "type": "synonym"
                },
                {
                    "name": "pp105",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma protein",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rb1",
                    "type": "recommended"
                },
                {
                    "name": "Rb-1",
                    "type": "synonym"
                },
                {
                    "name": "Rb1",
                    "type": "synonym"
                }
            ],
            "record_id": "P33568-1",
            "evidence": [
                {
                    "id": "0050804",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050804"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VF04-1",
            "uniprot_ac": "Q9VF04",
            "uniprot_id": "Q9VF04_DROME",
            "refseq_ac": "NP_524372",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG5083-PA",
                    "type": "synonym"
                },
                {
                    "name": "Rbf2-PA",
                    "type": "synonym"
                },
                {
                    "name": "Retinoblastoma-family protein 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rbf2",
                    "type": "recommended"
                },
                {
                    "name": "CG5083",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5083",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5083",
                    "type": "synonym"
                },
                {
                    "name": "RBF2",
                    "type": "synonym"
                },
                {
                    "name": "RBf2",
                    "type": "synonym"
                },
                {
                    "name": "RB",
                    "type": "synonym"
                },
                {
                    "name": "Rbf2",
                    "type": "synonym"
                },
                {
                    "name": "rbf2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VF04-1",
            "evidence": [
                {
                    "id": "0050804",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050804"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q96RI0-1",
            "uniprot_ac": "Q96RI0",
            "uniprot_id": "PAR4_HUMAN",
            "refseq_ac": "NP_003941",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Proteinase-activated receptor 4",
                    "type": "recommended"
                },
                {
                    "name": "Coagulation factor II receptor-like 3",
                    "type": "synonym"
                },
                {
                    "name": "F2R like thrombin/trypsin receptor 3",
                    "type": "synonym"
                },
                {
                    "name": "PAR-4",
                    "type": "synonym"
                },
                {
                    "name": "Thrombin receptor-like 3",
                    "type": "synonym"
                },
                {
                    "name": "coagulation factor II (thrombin) receptor-like 3",
                    "type": "synonym"
                },
                {
                    "name": "protease-activated receptor-4",
                    "type": "synonym"
                },
                {
                    "name": "proteinase-activated receptor 4 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "proteinase-activated receptor 4",
                    "type": "synonym"
                },
                {
                    "name": "thrombin receptor-like 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "F2RL3",
                    "type": "recommended"
                },
                {
                    "name": "F2RL3",
                    "type": "synonym"
                },
                {
                    "name": "PAR4",
                    "type": "synonym"
                }
            ],
            "record_id": "Q96RI0-1",
            "evidence": [
                {
                    "id": "0050804",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050804"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06400-1",
            "uniprot_ac": "P06400",
            "uniprot_id": "RB_HUMAN",
            "refseq_ac": "NP_000312",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Retinoblastoma-associated protein",
                    "type": "recommended"
                },
                {
                    "name": "Rb",
                    "type": "synonym"
                },
                {
                    "name": "p105-Rb",
                    "type": "synonym"
                },
                {
                    "name": "p110-RB1",
                    "type": "synonym"
                },
                {
                    "name": "pRb",
                    "type": "synonym"
                },
                {
                    "name": "pp110",
                    "type": "synonym"
                },
                {
                    "name": "prepro-retinoblastoma-associated protein",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 1, regulatory subunit 130",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma suspectibility protein",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma-associated protein isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoblastoma-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RB1",
                    "type": "recommended"
                },
                {
                    "name": "OSRC",
                    "type": "synonym"
                },
                {
                    "name": "PPP1R130",
                    "type": "synonym"
                },
                {
                    "name": "RB1",
                    "type": "synonym"
                },
                {
                    "name": "RB",
                    "type": "synonym"
                },
                {
                    "name": "p105-Rb",
                    "type": "synonym"
                },
                {
                    "name": "p110-RB1",
                    "type": "synonym"
                },
                {
                    "name": "pRb",
                    "type": "synonym"
                },
                {
                    "name": "pp110",
                    "type": "synonym"
                }
            ],
            "record_id": "P06400-1",
            "evidence": [
                {
                    "id": "0050804",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050804"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050804"
}