{
    "disease_id": "DOID:0050523",
    "recommended_name": {
        "id": "DOID:0050523",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050523",
        "name": "adult T-cell leukemia/lymphoma",
        "description": "A T-cell acute leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in human T-cell leukemia virus type 1 (Deltaretrovirus priTlym1), which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions."
    },
    "synonyms": [
        {
            "id": "DOID:0050523",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050523",
            "name": "ATLL",
            "description": ""
        },
        {
            "id": "DOID:0050523",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050523",
            "name": "adult T-cell leukemia",
            "description": ""
        },
        {
            "id": "DOID:0050523",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050523",
            "name": "Adult T-cell leukemia/lymphoma (HTLV-1 positive)",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050523"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050523",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050523",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "B0V237-1",
            "uniprot_ac": "B0V237",
            "uniprot_id": "B0V237_DANRE",
            "refseq_ac": "XP_002663133",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "jak3",
                    "type": "recommended"
                },
                {
                    "name": "jak3",
                    "type": "synonym"
                }
            ],
            "record_id": "B0V237-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ACD6B665-1",
            "uniprot_ac": "A0ACD6B665",
            "uniprot_id": "A0ACD6B665_DANRE",
            "refseq_ac": "XP_021323082",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 6",
                    "type": "recommended"
                },
                {
                    "name": "Apo-1 antigen",
                    "type": "synonym"
                },
                {
                    "name": "Apoptosis-mediating surface antigen FAS",
                    "type": "synonym"
                },
                {
                    "name": "FASLG receptor",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 6",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "fas",
                    "type": "recommended"
                },
                {
                    "name": "fas",
                    "type": "synonym"
                }
            ],
            "record_id": "A0ACD6B665-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P46530-1",
            "uniprot_ac": "P46530",
            "uniprot_id": "NOTC1_DANRE",
            "refseq_ac": "NP_571516",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Neurogenic locus notch homolog protein 1",
                    "type": "recommended"
                },
                {
                    "name": "Notch 1",
                    "type": "synonym"
                },
                {
                    "name": "deadly seven",
                    "type": "synonym"
                },
                {
                    "name": "neurogenic locus notch homolog protein 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "neurogenic locus notch homolog protein 1",
                    "type": "synonym"
                },
                {
                    "name": "notch 1a",
                    "type": "synonym"
                },
                {
                    "name": "notch 1",
                    "type": "synonym"
                },
                {
                    "name": "notch homolog 1a",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "notch1a",
                    "type": "recommended"
                },
                {
                    "name": "des",
                    "type": "synonym"
                },
                {
                    "name": "n1a",
                    "type": "synonym"
                },
                {
                    "name": "notch1a",
                    "type": "synonym"
                },
                {
                    "name": "notch",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc01e02",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc37a05",
                    "type": "synonym"
                }
            ],
            "record_id": "P46530-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
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            "uniprot_canonical_ac": "F1QUD8-1",
            "uniprot_ac": "F1QUD8",
            "uniprot_id": "F1QUD8_DANRE",
            "refseq_ac": "NP_958496",
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                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Stem cell protein",
                    "type": "recommended"
                },
                {
                    "name": "T-cell acute lymphocytic leukemia protein 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "tal2",
                    "type": "recommended"
                },
                {
                    "name": "tal2",
                    "type": "synonym"
                },
                {
                    "name": "zgc:111884",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QUD8-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M2BFY6-1",
            "uniprot_ac": "A0A8M2BFY6",
            "uniprot_id": "A0A8M2BFY6_DANRE",
            "refseq_ac": "XP_073807185",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Neurogenic locus notch homolog protein 1",
                    "type": "recommended"
                },
                {
                    "name": "neurogenic locus notch homolog protein 1b isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "notch1b",
                    "type": "recommended"
                },
                {
                    "name": "etID309871.5",
                    "type": "synonym"
                },
                {
                    "name": "notch1b",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc55e11",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2BFY6-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0AB32TBY4-1",
            "uniprot_ac": "A0AB32TBY4",
            "uniprot_id": "A0AB32TBY4_DANRE",
            "refseq_ac": "XP_068072052",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Uncharacterized protein si:ch211-241b2.5 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein si:ch211-241b2.5 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:ch211-241b2.5",
                    "type": "recommended"
                },
                {
                    "name": "si:ch211-241b2.5",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TBY4-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ACD6B5I3-1",
            "uniprot_ac": "A0ACD6B5I3",
            "uniprot_id": "A0ACD6B5I3_DANRE",
            "refseq_ac": "XP_002662849",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Lysosome-associated membrane glycoprotein 1",
                    "type": "synonym"
                },
                {
                    "name": "lysosome-associated membrane glycoprotein 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cd68",
                    "type": "recommended"
                },
                {
                    "name": "cd68",
                    "type": "synonym"
                }
            ],
            "record_id": "A0ACD6B5I3-1",
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                {
                    "id": "0050523",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0AB32TTK0-1",
            "uniprot_ac": "A0AB32TTK0",
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            "refseq_ac": "XP_068079112",
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            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Forkhead box protein P3a isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "forkhead box protein P3a isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "foxp3a",
                    "type": "recommended"
                },
                {
                    "name": "foxp3a",
                    "type": "synonym"
                },
                {
                    "name": "foxp3",
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            ],
            "record_id": "A0AB32TTK0-1",
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                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
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        {
            "uniprot_canonical_ac": "A0AC58G9P9-1",
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                {
                    "name": "Danio rerio",
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                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Forkhead box protein P3 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "forkhead box protein P3 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "foxp3b",
                    "type": "recommended"
                },
                {
                    "name": "foxp3b",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AC58G9P9-1",
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                {
                    "id": "0050523",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1QP24-1",
            "uniprot_ac": "F1QP24",
            "uniprot_id": "F1QP24_DANRE",
            "refseq_ac": "NP_001296751",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transcriptional activator Myb",
                    "type": "recommended"
                },
                {
                    "name": "transcription factor cmyb",
                    "type": "synonym"
                },
                {
                    "name": "transcriptional activator Myb isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "v-myb avian myeloblastosis viral oncogene homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "myb",
                    "type": "recommended"
                },
                {
                    "name": "c-myb",
                    "type": "synonym"
                },
                {
                    "name": "cmyb",
                    "type": "synonym"
                },
                {
                    "name": "myb",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QP24-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62137-1",
            "uniprot_ac": "Q62137",
            "uniprot_id": "JAK3_MOUSE",
            "refseq_ac": "NP_001177759",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase JAK3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "JAK-3",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Jak3",
                    "type": "recommended"
                },
                {
                    "name": "Jak3",
                    "type": "synonym"
                },
                {
                    "name": "fae",
                    "type": "synonym"
                },
                {
                    "name": "wil",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62137-1",
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                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P25446-1",
            "uniprot_ac": "P25446",
            "uniprot_id": "TNR6_MOUSE",
            "refseq_ac": "NP_032013",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 6",
                    "type": "recommended"
                },
                {
                    "name": "Apo-1 antigen",
                    "type": "synonym"
                },
                {
                    "name": "Apoptosis-mediating surface antigen FAS",
                    "type": "synonym"
                },
                {
                    "name": "FASLG receptor",
                    "type": "synonym"
                },
                {
                    "name": "Fas (TNF receptor superfamily member 6)",
                    "type": "synonym"
                },
                {
                    "name": "Fas (TNF receptor superfamily member)",
                    "type": "synonym"
                },
                {
                    "name": "Fas antigen",
                    "type": "synonym"
                },
                {
                    "name": "apo-1 antigen",
                    "type": "synonym"
                },
                {
                    "name": "apoptosis-mediating surface antigen FAS",
                    "type": "synonym"
                },
                {
                    "name": "lymphoproliferation",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 6 isoform 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Fas",
                    "type": "recommended"
                },
                {
                    "name": "APO1",
                    "type": "synonym"
                },
                {
                    "name": "APT1",
                    "type": "synonym"
                },
                {
                    "name": "Apt1",
                    "type": "synonym"
                },
                {
                    "name": "CD95",
                    "type": "synonym"
                },
                {
                    "name": "Fas",
                    "type": "synonym"
                },
                {
                    "name": "TNFR6",
                    "type": "synonym"
                },
                {
                    "name": "Tnfrsf6",
                    "type": "synonym"
                },
                {
                    "name": "lpr",
                    "type": "synonym"
                }
            ],
            "record_id": "P25446-1",
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                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q01705-1",
            "uniprot_ac": "Q01705",
            "uniprot_id": "NOTC1_MOUSE",
            "refseq_ac": "NP_032740",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Neurogenic locus notch homolog protein 1",
                    "type": "recommended"
                },
                {
                    "name": "Motch A",
                    "type": "synonym"
                },
                {
                    "name": "Notch 1",
                    "type": "synonym"
                },
                {
                    "name": "Notch gene homolog 1",
                    "type": "synonym"
                },
                {
                    "name": "mT14",
                    "type": "synonym"
                },
                {
                    "name": "major type A protein",
                    "type": "synonym"
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                {
                    "name": "neurogenic locus notch homolog protein 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "neurogenic locus notch homolog protein 1",
                    "type": "synonym"
                },
                {
                    "name": "p300",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Notch1",
                    "type": "recommended"
                },
                {
                    "name": "9930111A19Rik",
                    "type": "synonym"
                },
                {
                    "name": "Mis6",
                    "type": "synonym"
                },
                {
                    "name": "Motch",
                    "type": "synonym"
                },
                {
                    "name": "N1",
                    "type": "synonym"
                },
                {
                    "name": "Notch1",
                    "type": "synonym"
                },
                {
                    "name": "Tan1",
                    "type": "synonym"
                },
                {
                    "name": "lin-12",
                    "type": "synonym"
                }
            ],
            "record_id": "Q01705-1",
            "evidence": [
                {
                    "id": "0050523",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050523"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62282-1",
            "uniprot_ac": "Q62282",
            "uniprot_id": "TAL2_MOUSE",
            "refseq_ac": "NP_033343",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "T-cell acute lymphocytic leukemia protein 2 homolog",
                    "type": "recommended"
                },
                {
                    "name": "T-cell acute lymphocytic leukemia protein 2 homolog",
                    "type": "synonym"
                },
                {
                    "name": "TAL-2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tal2",
                    "type": "recommended"
                },
                {
                    "name": "Tal2",
                    "type": "synonym"
                },
                {
                    "name": "bHLHa19",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62282-1",
            "evidence": [
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                    "id": "0050523",
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                {
                    "name": "BB1",
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                {
                    "name": "CD28LG1",
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                {
                    "name": "CD28LG",
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                    "name": "CD80",
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                    "name": "LAB7",
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                }
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                {
                    "name": "B-lymphocyte activation antigen B7-2",
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                    "name": "B70",
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                {
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                {
                    "name": "T-lymphocyte activation antigen CD86 isoform 4 precursor",
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            ],
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                {
                    "name": "Notch homolog 1, translocation-associated",
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                {
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                    "name": "TAN1",
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                    "name": "Class A basic helix-loop-helix protein 19",
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                {
                    "name": "T-cell acute lymphocytic leukemia 2",
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                    "name": "T-cell acute lymphocytic leukemia protein 2",
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                    "name": "TAL-2",
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                    "name": "bHLHa19",
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                {
                    "name": "Leukocyte janus kinase",
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                {
                    "name": "leukocyte Janus kinase",
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    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050523"
}