{ "disease_id": "DOID:0050426", "recommended_name": { "id": "DOID:0050426", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050426", "name": "Stevens-Johnson syndrome", "description": "A skin disease that is characterized by ulceration of less than 10 percent of the surface area of the body. The disease is often precipitated by the use of medications, such as antibiotics or antiepileptics, or onset of infection." }, "synonyms": [ { "id": "MONDO:0018229", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018229", "name": "Stevens-Johnson syndrome", "description": "Stevens-Johnson syndrome is a limited form of toxic epidermal necrolysis characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area." }, { "id": "MONDO:0018229", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018229", "name": "Dermatostomatitis, Stevens Johnson type", "description": "" }, { "id": "MONDO:0018229", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018229", "name": "Stevens Johnson syndrome", "description": "" }, { "id": "MIM:608579", "resource": "MIM", "url": "https://www.omim.org/entry/608579", "name": "Stevens-Johnson syndrome", "description": "Stevens-Johnson syndrome" } ], "children": [], "id_list": [ "DOID:0050426" ], "unlinked_id_list": [], "crossref": [ { "id": "DOID:0050426", "database": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050426", "categories": [] }, { "id": "MONDO:0018229", "database": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018229", "categories": [] }, { "id": "MIM:608579", "database": "MIM", "url": "https://www.omim.org/entry/608579", "categories": [] } ], "proteins": [ { "uniprot_canonical_ac": "A0A8M2B5P7-1", "uniprot_ac": "A0A8M2B5P7", "uniprot_id": "A0A8M2B5P7_DANRE", "refseq_ac": "XP_005159251", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "Major histocompatibility complex class II DBB isoform X1", "type": "synonym" }, { "name": "major histocompatibility complex class II DBB isoform X1", "type": "synonym" } ], "gene_names": [ { "name": "mhc2dbb", "type": "recommended" }, { "name": "DBB", "type": "synonym" }, { "name": "mhc2d18b", "type": "synonym" }, { "name": "mhc2dbb", "type": "synonym" }, { "name": "si:busm1-241h12.1", "type": "synonym" }, { "name": "si:dz241h12.1", "type": "synonym" }, { "name": "zgc:153067", "type": "synonym" } ], "record_id": "A0A8M2B5P7-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0A8M1NAM7-1", "uniprot_ac": "A0A8M1NAM7", "uniprot_id": "A0A8M1NAM7_DANRE", "refseq_ac": "NP_001071221", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "MHC class II", "type": "synonym" }, { "name": "Uncharacterized protein LOC368846 precursor", "type": "synonym" }, { "name": "uncharacterized protein LOC368846 precursor", "type": "synonym" } ], "gene_names": [ { "name": "mhc2d8.45b1", "type": "recommended" }, { "name": "mhc2d8.45b1", "type": "synonym" }, { "name": "si:busm1-228j01.6", "type": "synonym" }, { "name": "si:dz228j01.6", "type": "synonym" } ], "record_id": "A0A8M1NAM7-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0A8M2BI98-1", "uniprot_ac": "A0A8M2BI98", "uniprot_id": "A0A8M2BI98_DANRE", "refseq_ac": "XP_005171048", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "Major histocompatibility complex class I ZDA isoform X1", "type": "synonym" }, { "name": "major histocompatibility complex class I ZDA isoform X1", "type": "synonym" } ], "gene_names": [ { "name": "mhc1zda", "type": "recommended" }, { "name": "mhc1zda", "type": "synonym" } ], "record_id": "A0A8M2BI98-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0A8M1PBT2-1", "uniprot_ac": "A0A8M1PBT2", "uniprot_id": "A0A8M1PBT2_DANRE", "refseq_ac": "NP_957096", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "Clusterin", "type": "recommended" }, { "name": "clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)", "type": "synonym" }, { "name": "clusterin precursor", "type": "synonym" } ], "gene_names": [ { "name": "clu", "type": "recommended" }, { "name": "clu", "type": "synonym" }, { "name": "zgc:73352", "type": "synonym" } ], "record_id": "A0A8M1PBT2-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "Q4W898-1", "uniprot_ac": "Q4W898", "uniprot_id": "Q4W898_DANRE", "refseq_ac": "NP_001019618", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "Lymphotoxin-alpha", "type": "recommended" }, { "name": "TNF alpha", "type": "synonym" }, { "name": "TNF-alpha 2", "type": "synonym" }, { "name": "TNF-alpha", "type": "synonym" }, { "name": "TNF-beta", "type": "synonym" }, { "name": "TNF2", "type": "synonym" }, { "name": "Tumor necrosis factor ligand superfamily member 1", "type": "synonym" }, { "name": "Tumor necrosis factor", "type": "synonym" }, { "name": "lta", "type": "synonym" }, { "name": "tumor necrosis factor (TNF superfamily, member 2)", "type": "synonym" }, { "name": "tumor necrosis factor alpha", "type": "synonym" }, { "name": "tumor necrosis factor b (TNF superfamily, member 2)", "type": "synonym" } ], "gene_names": [ { "name": "tnfb", "type": "recommended" }, { "name": "Tnf-alpha", "type": "synonym" }, { "name": "tnfa-like", "type": "synonym" }, { "name": "tnfb", "type": "synonym" }, { "name": "tnf", "type": "synonym" } ], "record_id": "Q4W898-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0A8M9Q7W9-1", "uniprot_ac": "A0A8M9Q7W9", "uniprot_id": "A0A8M9Q7W9_DANRE", "refseq_ac": "XP_021331586", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "NF-kappa-B inhibitor zeta isoform X1", "type": "synonym" } ], "gene_names": [ { "name": "nfkbiz", "type": "recommended" }, { "name": "nfkbiz", "type": "synonym" } ], "record_id": "A0A8M9Q7W9-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "Q9EST8-1", "uniprot_ac": "Q9EST8", "uniprot_id": "IKBZ_MOUSE", "refseq_ac": "NP_001152866", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "NF-kappa-B inhibitor zeta", "type": "recommended" }, { "name": "I-kappa-B-zeta", "type": "synonym" }, { "name": "IL-1 inducible nuclear ankyrin-repeat protein", "type": "synonym" }, { "name": "INAP", "type": "synonym" }, { "name": "IkB-zeta", "type": "synonym" }, { "name": "IkappaB-zeta", "type": "synonym" }, { "name": "IkappaBzeta", "type": "synonym" }, { "name": "MAIL", "type": "synonym" }, { "name": "Molecule possessing ankyrin repeats induced by lipopolysaccharide", "type": "synonym" }, { "name": "NF-kappa-B inhibitor zeta isoform a", "type": "synonym" }, { "name": "NF-kappa-B inhibitor zeta", "type": "synonym" }, { "name": "ikB-zeta", "type": "synonym" }, { "name": "ikappaBzeta", "type": "synonym" }, { "name": "molecule possessing ankyrin-repeats induced by lipopolysaccharide", "type": "synonym" } ], "gene_names": [ { "name": "Nfkbiz", "type": "recommended" }, { "name": "INAP", "type": "synonym" }, { "name": "Inap", "type": "synonym" }, { "name": "Mail", "type": "synonym" }, { "name": "Nfkbiz", "type": "synonym" } ], "record_id": "Q9EST8-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P15626-1", "uniprot_ac": "P15626", "uniprot_id": "GSTM2_MOUSE", "refseq_ac": "NP_032209", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Glutathione S-transferase Mu 2", "type": "recommended" }, { "name": "2.5.1.18", "type": "synonym" }, { "name": "GST 5-5", "type": "synonym" }, { "name": "GST class-mu 2", "type": "synonym" }, { "name": "Glutathione S-transferase pmGT2", "type": "synonym" }, { "name": "glutathione S-transferase Mu 2", "type": "synonym" }, { "name": "glutathione S-transferase pmGT2", "type": "synonym" } ], "gene_names": [ { "name": "Gstm2", "type": "recommended" }, { "name": "Gstb-2", "type": "synonym" }, { "name": "Gstb2", "type": "synonym" }, { "name": "Gstm2", "type": "synonym" } ], "record_id": "P15626-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P10649-1", "uniprot_ac": "P10649", "uniprot_id": "GSTM1_MOUSE", "refseq_ac": "NP_034488", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Glutathione S-transferase Mu 1", "type": "recommended" }, { "name": "2.5.1.18", "type": "synonym" }, { "name": "GST 1-1", "type": "synonym" }, { "name": "GST class-mu 1", "type": "synonym" }, { "name": "Glutathione S-transferase GT8.7", "type": "synonym" }, { "name": "glutathione S-transferase GT8.7", "type": "synonym" }, { "name": "glutathione S-transferase Mu 1 isoform 2", "type": "synonym" }, { "name": "pmGT10", "type": "synonym" } ], "gene_names": [ { "name": "Gstm1", "type": "recommended" }, { "name": "Gstb-1", "type": "synonym" }, { "name": "Gstb1", "type": "synonym" }, { "name": "Gstm1", "type": "synonym" } ], "record_id": "P10649-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P01921-1", "uniprot_ac": "P01921", "uniprot_id": "HB2D_MOUSE", "refseq_ac": "", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "H-2 class II histocompatibility antigen, A-D beta chain", "type": "recommended" } ], "gene_names": [ { "name": "H2-Ab1", "type": "recommended" }, { "name": "H2-iabeta", "type": "synonym" } ], "record_id": "P01921-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "O35660-1", "uniprot_ac": "O35660", "uniprot_id": "GSTM6_MOUSE", "refseq_ac": "NP_032210", "glycoprotein": "no", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Glutathione S-transferase Mu 6", "type": "recommended" }, { "name": "2.5.1.18", "type": "synonym" }, { "name": "GST class-mu 6", "type": "synonym" }, { "name": "Glutathione-S-transferase class M5", "type": "synonym" }, { "name": "glutathione S-transferase Mu 6 isoform 4", "type": 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S-transferase GT9.3", "type": "synonym" }, { "name": "glutathione S-transferase Mu 3", "type": "synonym" } ], "gene_names": [ { "name": "Gstm3", "type": "recommended" }, { "name": "Fsc2", "type": "synonym" }, { "name": "Gstm3", "type": "synonym" }, { "name": "mGSTM5", "type": "synonym" } ], "record_id": "P19639-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P01901-1", "uniprot_ac": "P01901", "uniprot_id": "HA1B_MOUSE", "refseq_ac": "NP_001001892", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "H-2 class I histocompatibility antigen, K-B alpha chain", "type": "recommended" }, { "name": "H-2 class I histocompatibility antigen, K-B alpha chain", "type": "synonym" }, { "name": "H-2 class I histocompatibility antigen, K-D alpha 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class I histocompatibility antigen, Q10 alpha chain", "type": "recommended" }, { "name": "H-2 class I histocompatibility antigen, Q10 alpha chain precursor", "type": "synonym" }, { "name": "H-2 class I histocompatibility antigen, Q10 alpha chain", "type": "synonym" }, { "name": "MHC class I transplantation antigen", "type": "synonym" }, { "name": "MHC class II antigen K", "type": "synonym" } ], "gene_names": [ { "name": "H2-Q10", "type": "recommended" }, { "name": "H-2Q10", "type": "synonym" }, { "name": "H2-K1", "type": "synonym" }, { "name": "H2-Q10", "type": "synonym" }, { "name": "Q10", "type": "synonym" }, { "name": "Qa10", "type": "synonym" } ], "record_id": "P01898-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P14429-1", "uniprot_ac": "P14429", "uniprot_id": "HA17_MOUSE", "refseq_ac": "NP_034524", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "H-2 class I histocompatibility antigen, Q7 alpha chain", "type": "recommended" }, { "name": "H-2 class I histocompatibility antigen, Q7 alpha chain isoform 1 precursor", "type": "synonym" }, { "name": "H-2 class I histocompatibility antigen, Q7 alpha chain", "type": "synonym" }, { "name": "QA-2 antigen", "type": "synonym" }, { "name": "class Ib MHC antigen Qa-2", "type": "synonym" } ], "gene_names": [ { "name": "H2-Q7", "type": "recommended" }, { "name": "H-2Q7", "type": "synonym" }, { "name": "H2-Q4", "type": "synonym" }, { "name": "H2-Q7", "type": "synonym" }, { "name": "Ped", "type": "synonym" }, { "name": "Q9", "type": "synonym" }, { "name": "Qa-2", "type": "synonym" }, { "name": "Qa-7", "type": "synonym" }, { "name": "Qa7", "type": "synonym" } ], "record_id": "P14429-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P14427-1", "uniprot_ac": "P14427", "uniprot_id": "HA14_MOUSE", "refseq_ac": "", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "H-2 class I histocompatibility antigen, D-P alpha chain", "type": "recommended" }, { "name": "H-2D(P)", "type": "synonym" } ], "gene_names": [ { "name": "H2-D1", "type": "recommended" } ], "record_id": "P14427-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P79568-1", "uniprot_ac": "P79568", "uniprot_id": "P79568_MOUSE", "refseq_ac": "NP_997531", "glycoprotein": "no", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], 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"https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "Q6W9L1-1", "uniprot_ac": "Q6W9L1", "uniprot_id": "Q6W9L1_MOUSE", "refseq_ac": "NP_001334316", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Histocompatibility 2, M region locus 2", "type": "synonym" }, { "name": "histocompatibility 2, M region locus 2 precursor", "type": "synonym" } ], "gene_names": [ { "name": "H2-M2", "type": "recommended" }, { "name": "H-2M2", "type": "synonym" }, { "name": "H2-M2", "type": "synonym" }, { "name": "Thy19.4", "type": "synonym" } ], "record_id": "Q6W9L1-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "P01897-1", "uniprot_ac": "P01897", "uniprot_id": "HA1L_MOUSE", "refseq_ac": "", "glycoprotein": "yes", 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"https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0ABK0L3M9-1", "uniprot_ac": "A0ABK0L3M9", "uniprot_id": "A0ABK0L3M9_RAT", "refseq_ac": "", "glycoprotein": "no", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "protein_names": [ { "name": "RT1 class I, locus1", "type": "synonym" } ], "gene_names": [ { "name": "RT1-CE1", "type": "recommended" } ], "record_id": "A0ABK0L3M9-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "A0A8I6AQ52-1", "uniprot_ac": "A0A8I6AQ52", "uniprot_id": "A0A8I6AQ52_RAT", "refseq_ac": "NP_001008886", "glycoprotein": "no", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "protein_names": [ { "name": "MHC class 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[10116]" } ], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended" } ], "gene_names": [ { "name": "RT1-M10-ps5", "type": "recommended" }, { "name": "AABR07044308.2", "type": "synonym" }, { "name": "H2-m10.6l", "type": "synonym" } ], "record_id": "A0A8I5ZYQ2-1", "evidence": [ { "id": "0050426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050426" } ] }, { "uniprot_canonical_ac": "Q6W9J5-1", "uniprot_ac": "Q6W9J5", "uniprot_id": "Q6W9J5_RAT", "refseq_ac": "NP_001001717", "glycoprotein": "no", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "protein_names": [ { "name": "RT1 class Ib, locus M2 precursor", "type": "synonym" }, { "name": "RT1 class Ib, locus M2", "type": "synonym" } ], "gene_names": [ { "name": "RT1-M2", "type": "recommended" }, { "name": "RT1-M2", "type": "synonym" } ], "record_id": "Q6W9J5-1", 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