{
    "biomarker_id": "BD0291-1",
    "biomarker_canonical_id": "BD0291",
    "condition": {
        "recommended_name": {
            "id": "DOID:0070658",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070658",
            "name": "alcohol-associated liver disease",
            "description": "A liver disease resulting from excessive alcohol intake."
        },
        "synonyms": [
            {
                "id": "DOID:0070658",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0070658",
                "name": "ALD",
                "description": ""
            },
            {
                "id": "DOID:0070658",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0070658",
                "name": "alcohol-related liver disease",
                "description": ""
            },
            {
                "id": "DOID:0070658",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0070658",
                "name": "alcoholic liver disease",
                "description": ""
            }
        ],
        "id": "DOID:0070658"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of K18-M65",
            "assessed_biomarker_entity_id": "P05783-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Keratin, type I cytoskeletal 18",
                "synonyms": [
                    {
                        "synonym": "Keratin-18"
                    },
                    {
                        "synonym": "K18"
                    },
                    {
                        "synonym": "Cytokeratin-18"
                    },
                    {
                        "synonym": "CK-18"
                    },
                    {
                        "synonym": "Cell proliferation-inducing gene 46 protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BD0291-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BD0291-1"
                },
                {
                    "id": "37060262",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "High levels of K18-M65 characterized AUD patients with early ALD while levels in the minimal ALD group were similar to those in healthy controls. Serum K18-M65 can be used as a biomarker to detect early ALD stages with an excellent predictive value."
                        }
                    ]
                },
                {
                    "id": "33156105",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Total (K18-M65) and caspase-cleaved K18 (K18-M30) were quantified in pretreatment sera... K18 fragments were markedly elevated in severe AH and strongly predicted steatohepatitis (alcoholic steatohepatitis)... In a large cohort of patients with severe AH, serum K18 strongly correlated with histological severity, independently associated with 90-day mortality, and predicted response to prednisolone therapy. Quantification of serum K18 levels could assist in clinical decision-making."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "BD0291-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BD0291-1"
        },
        {
            "id": "37060262",
            "database": "PubMed",
            "url": "",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "High levels of K18-M65 characterized AUD patients with early ALD while levels in the minimal ALD group were similar to those in healthy controls. Serum K18-M65 can be used as a biomarker to detect early ALD stages with an excellent predictive value."
                }
            ]
        },
        {
            "id": "33156105",
            "database": "PubMed",
            "url": "",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Total (K18-M65) and caspase-cleaved K18 (K18-M30) were quantified in pretreatment sera... K18 fragments were markedly elevated in severe AH and strongly predicted steatohepatitis (alcoholic steatohepatitis)... In a large cohort of patients with severe AH, serum K18 strongly correlated with histological severity, independently associated with 90-day mortality, and predicted response to prednisolone therapy. Quantification of serum K18 levels could assist in clinical decision-making."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BD0291-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BD0291-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}