{
    "biomarker_id": "BB3879-3",
    "biomarker_canonical_id": "BB3879",
    "condition": {
        "recommended_name": {
            "id": "DOID:9074",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9074",
            "name": "systemic lupus erythematosus",
            "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart."
        },
        "synonyms": [
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "SLE - Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific."
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "Lupus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE - lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus (disease)",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "SLEB15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "SLEB3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "SLEB4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "SLEB5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "SLEB6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "SLEB7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "SLEB8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "SLEB12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "SLEB13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "SLEB14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "autosomal systemic lupus erythematosus type 16",
                "description": "An instance of systemic lupus erythematosus (disease) that is caused by mutations in DNASE1L3."
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "SLEB16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus 16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus related to DNASE1L3",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus type 16",
                "description": ""
            },
            {
                "id": "MIM:152700",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/152700",
                "name": "Systemic lupus erythematosus",
                "description": "Systemic lupus erythematosus"
            },
            {
                "id": "MIM:609939",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/609939",
                "name": "Systemic lupus erythematosus 6",
                "description": "Systemic lupus erythematosus 6"
            },
            {
                "id": "MIM:614420",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/614420",
                "name": "Systemic lupus erythematosus 16",
                "description": "Systemic lupus erythematosus 16"
            }
        ],
        "id": "DOID:9074"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of galactose on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3879-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3879-3"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "A higher binding level of PNA (preferred to Gal) was confirmed in patients with SLE than in HCs, pSS and RA. Among these, PNA binding levels in the lectin microarray analysis provided better differentiation conditions between SLE and pSS with a sensitivity of 92.8, specificity of 65.0% and area under the curve value of 0.775 (95% CI: 0.676 to 0.874, p<0.001), though it just showed medium potential."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3879-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3879-3"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "A higher binding level of PNA (preferred to Gal) was confirmed in patients with SLE than in HCs, pSS and RA. Among these, PNA binding levels in the lectin microarray analysis provided better differentiation conditions between SLE and pSS with a sensitivity of 92.8, specificity of 65.0% and area under the curve value of 0.775 (95% CI: 0.676 to 0.874, p<0.001), though it just showed medium potential."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3879-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3879-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}