{
    "biomarker_id": "BB3879-1",
    "biomarker_canonical_id": "BB3879",
    "condition": {
        "recommended_name": {
            "id": "DOID:8857",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:8857",
            "name": "lupus erythematosus",
            "description": "An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs."
        },
        "synonyms": [
            {
                "id": "DOID:8857",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:8857",
                "name": "lupus",
                "description": ""
            }
        ],
        "id": "DOID:8857"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of galactose on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3879-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3879-1"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Gal\u03b23GalNAc and galactose patterns in NPSLE and LN compared to HCs. Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC. In our study, we found that the IgG glycan levels were higher for galactose in the NPSLE versus WMOI group. Our article found that compared with the WMOI group, the NPSLE group had patients who might experience higher IgG glycan levels of galactose. Aberrant Gal\u03b23GalNAc, galactose and GalNAc glycosylation may offer potential diagnostic value for SLE and NPSLE."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3879-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3879-1"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Gal\u03b23GalNAc and galactose patterns in NPSLE and LN compared to HCs. Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC. In our study, we found that the IgG glycan levels were higher for galactose in the NPSLE versus WMOI group. Our article found that compared with the WMOI group, the NPSLE group had patients who might experience higher IgG glycan levels of galactose. Aberrant Gal\u03b23GalNAc, galactose and GalNAc glycosylation may offer potential diagnostic value for SLE and NPSLE."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3879-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3879-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}