{
    "biomarker_id": "BB3878-2",
    "biomarker_canonical_id": "BB3878",
    "condition": {
        "recommended_name": {
            "id": "DOID:8857",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:8857",
            "name": "lupus erythematosus",
            "description": "An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs."
        },
        "synonyms": [
            {
                "id": "DOID:8857",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:8857",
                "name": "lupus",
                "description": ""
            }
        ],
        "id": "DOID:8857"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of Gal\u03b24GlcNAc on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3878-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3878-2"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3878-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3878-2"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3878-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3878-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}