{
    "biomarker_id": "BB3878-1",
    "biomarker_canonical_id": "BB3878",
    "condition": {
        "recommended_name": {
            "id": "DOID:9074",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9074",
            "name": "systemic lupus erythematosus",
            "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart."
        },
        "synonyms": [
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "SLE - Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific."
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "Lupus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE - lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus (disease)",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "SLEB15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "SLEB3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "SLEB4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "SLEB5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "SLEB6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "SLEB7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "SLEB8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "SLEB12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "SLEB13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "SLEB14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "autosomal systemic lupus erythematosus type 16",
                "description": "An instance of systemic lupus erythematosus (disease) that is caused by mutations in DNASE1L3."
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "SLEB16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus 16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus related to DNASE1L3",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus type 16",
                "description": ""
            },
            {
                "id": "MIM:152700",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/152700",
                "name": "Systemic lupus erythematosus",
                "description": "Systemic lupus erythematosus"
            },
            {
                "id": "MIM:609939",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/609939",
                "name": "Systemic lupus erythematosus 6",
                "description": "Systemic lupus erythematosus 6"
            },
            {
                "id": "MIM:614420",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/614420",
                "name": "Systemic lupus erythematosus 16",
                "description": "Systemic lupus erythematosus 16"
            }
        ],
        "id": "DOID:9074"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of Gal\u03b24GlcNAc on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3878-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3878-1"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Compared to DC and HC groups, the IgG glycan level of Gal\u03b23GalNAc (binding Jacalin (11.3%) and Maclura pomifera lectin (14.4%)) was significantly increased, whereas most IgG glycan levels were significantly decreased, including core fucose, high mannose, GlcNAc, GalNAc and Gal\u03b24GlcNAc in the SLE group (all p<0.05). For patients with SLE compared with HC and DC, most IgG glycan levels were significantly decreased, including core fucose (Fuc, binding PSA), high mannose (Man, binding NPL, GNL (1%), HHL (0%) and VVA), N-Acetylglucosamine (GlcNAc, binding UDA and PWM), N-Acetylgalactosamine (GalNAc, binding Black bean crude) and Gal\u03b24GlcNAc (binding PHA-E)."
                        },
                        {
                            "evidence": "As for the WMOI group, glycan levels of lgG galactose (binding GHA), GalNAc (binding CSA) and Gal\u03b24GlcNAc (binding MAL I) were significantly lower than NPSLE and HC."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3878-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3878-1"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Compared to DC and HC groups, the IgG glycan level of Gal\u03b23GalNAc (binding Jacalin (11.3%) and Maclura pomifera lectin (14.4%)) was significantly increased, whereas most IgG glycan levels were significantly decreased, including core fucose, high mannose, GlcNAc, GalNAc and Gal\u03b24GlcNAc in the SLE group (all p<0.05). For patients with SLE compared with HC and DC, most IgG glycan levels were significantly decreased, including core fucose (Fuc, binding PSA), high mannose (Man, binding NPL, GNL (1%), HHL (0%) and VVA), N-Acetylglucosamine (GlcNAc, binding UDA and PWM), N-Acetylgalactosamine (GalNAc, binding Black bean crude) and Gal\u03b24GlcNAc (binding PHA-E)."
                },
                {
                    "evidence": "As for the WMOI group, glycan levels of lgG galactose (binding GHA), GalNAc (binding CSA) and Gal\u03b24GlcNAc (binding MAL I) were significantly lower than NPSLE and HC."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3878-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3878-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
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                }
            ],
            "sort_fields": []
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    ]
}