{
    "biomarker_id": "BB3874-3",
    "biomarker_canonical_id": "BB3874",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080162",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080162",
            "name": "lupus nephritis",
            "description": "A glomerulonephritis that is characterized by inflammation of the kidneys resulting from systemic lupus erythematosus."
        },
        "synonyms": [],
        "id": "DOID:0080162"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of Gal\u03b23GalNAc on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3874-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3874-3"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Gal\u03b23GalNAc and galactose patterns in NPSLE and LN compared to HCs. Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3874-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3874-3"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Gal\u03b23GalNAc and galactose patterns in NPSLE and LN compared to HCs. Looking into differences of each subgroup compared with HC (with no difference between WMOI vs HC), the glycan levels of lgG galactose (binding GSL I-B4 and PNA (13.3% and 28.3%)), Gal\u03b23GalNAc (binding MPL) were significantly higher in NPSLE and LN vs HC, while IgG core fucose (binding PSA) and Gal\u03b24GlcNAc (binding PHA-E) levels were significantly reduced within NPSLE versus HC."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3874-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3874-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}