{
    "biomarker_id": "BB3864-1",
    "biomarker_canonical_id": "BB3864",
    "condition": {
        "recommended_name": {
            "id": "DOID:13208",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:13208",
            "name": "background diabetic retinopathy",
            "description": ""
        },
        "synonyms": [
            {
                "id": "DOID:13208",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:13208",
                "name": "Non proliferative diabetic retinopathy",
                "description": ""
            },
            {
                "id": "DOID:13208",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:13208",
                "name": "Non-Proliferative Diabetic Retinopathy",
                "description": ""
            }
        ],
        "id": "DOID:13208"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of G1F on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3864-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3864-1"
                },
                {
                    "id": "40204274",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Significant differences in 9 DSIgG N-glycopeptide ratios (DSIgG1: G1F/G0F, G1FN/G0FN, G2F/G0F, G2F/G1F; DSIgG2: G1F/G0F, G1FN/G0FN, G2/G1, G2F/G0F, G2F/G1F) were found between NDR, NPDR and PDR groups and are displayed in Figure 2. Eight glycopeptide ratios (DSIgG1: G1F/G0F, G1FN/G0FN, G2F/G0F; DSIgG2: G1F/G0F, G1FN/G0FN, G2/G1, G2F/G0F, G2F/G1F) were found to be significantly different between NDR and NPDR groups. Six glycopeptide ratios (DSIgG1: G1F/G0F, G2F/G0F; DSIgG2: G1F/G0F, G2/G1, G2F/G0F, G2F/G1F) were found to be significantly different between NDR and PDR groups. It was found that patients with NDR have the highest tendency of galactosylation, while patients with NPDR have the lowest. Patients with severe NPDR have a lower tendency of galactosylation and a higher tendency for fucosylation, demonstrating that patients with severe NPDR manifest a higher status of inflammatory response. Nine DSIgG N-glycopeptide ratios were found to be significantly different among the NDR, NPDR, and PDR groups in this study."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3864-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3864-1"
        },
        {
            "id": "40204274",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Significant differences in 9 DSIgG N-glycopeptide ratios (DSIgG1: G1F/G0F, G1FN/G0FN, G2F/G0F, G2F/G1F; DSIgG2: G1F/G0F, G1FN/G0FN, G2/G1, G2F/G0F, G2F/G1F) were found between NDR, NPDR and PDR groups and are displayed in Figure 2. Eight glycopeptide ratios (DSIgG1: G1F/G0F, G1FN/G0FN, G2F/G0F; DSIgG2: G1F/G0F, G1FN/G0FN, G2/G1, G2F/G0F, G2F/G1F) were found to be significantly different between NDR and NPDR groups. Six glycopeptide ratios (DSIgG1: G1F/G0F, G2F/G0F; DSIgG2: G1F/G0F, G2/G1, G2F/G0F, G2F/G1F) were found to be significantly different between NDR and PDR groups. It was found that patients with NDR have the highest tendency of galactosylation, while patients with NPDR have the lowest. Patients with severe NPDR have a lower tendency of galactosylation and a higher tendency for fucosylation, demonstrating that patients with severe NPDR manifest a higher status of inflammatory response. Nine DSIgG N-glycopeptide ratios were found to be significantly different among the NDR, NPDR, and PDR groups in this study."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3864-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3864-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}