{
    "biomarker_id": "BB3852-1",
    "biomarker_canonical_id": "BB3852",
    "condition": {
        "recommended_name": {
            "id": "DOID:3910",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3910",
            "name": "lung adenocarcinoma",
            "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin."
        },
        "synonyms": [
            {
                "id": "DOID:3910",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3910",
                "name": "bronchogenic lung adenocarcinoma",
                "description": ""
            },
            {
                "id": "DOID:3910",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3910",
                "name": "nonsmall cell adenocarcinoma",
                "description": ""
            }
        ],
        "id": "DOID:3910"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of H3N2 on CEACAM5",
            "assessed_biomarker_entity_id": "P06731-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Carcinoembryonic antigen-related cell adhesion molecule 5",
                "synonyms": [
                    {
                        "synonym": "Carcinoembryonic antigen"
                    },
                    {
                        "synonym": "CEA"
                    },
                    {
                        "synonym": "Meconium antigen 100"
                    },
                    {
                        "synonym": "Carcinoembryonic antigen-related cell adhesion molecule 5"
                    },
                    {
                        "synonym": "CEA cell adhesion molecule 5"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "tissue",
                    "namespace": "UBERON",
                    "id": "0000479",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000479",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3852-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3852-1"
                },
                {
                    "id": "40175289",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "For example, the increase of N197/553 H3N2 and H5N2 on CEAM5 in tumor regions can be partially due to the overexpression of CEAM5 itself; on the other hand, the decrease of IQGA1 N1449 F1H5N4S1 is likely affected only by N-glycosylation events. 50 In our results, CEAM5 was highly (more than 10 times higher) and CEAM6 was moderately overexpressed in tumor tissue, while we also found changes in the abundance of 3 N-glycopeptides. For CEAM5 N-glycopeptides, the large increase in abundance is likely due to the increase in glycoprotein expression, but for CEAM6 N197 H5N2 the increase in N-glycopeptide abundance is much greater than for the glycoprotein."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3852-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3852-1"
        },
        {
            "id": "40175289",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "For example, the increase of N197/553 H3N2 and H5N2 on CEAM5 in tumor regions can be partially due to the overexpression of CEAM5 itself; on the other hand, the decrease of IQGA1 N1449 F1H5N4S1 is likely affected only by N-glycosylation events. 50 In our results, CEAM5 was highly (more than 10 times higher) and CEAM6 was moderately overexpressed in tumor tissue, while we also found changes in the abundance of 3 N-glycopeptides. For CEAM5 N-glycopeptides, the large increase in abundance is likely due to the increase in glycoprotein expression, but for CEAM6 N197 H5N2 the increase in N-glycopeptide abundance is much greater than for the glycoprotein."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3852-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3852-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}