{
    "biomarker_id": "BB3850-1",
    "biomarker_canonical_id": "BB3850",
    "condition": {
        "recommended_name": {
            "id": "DOID:1496",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1496",
            "name": "echinococcosis",
            "description": "A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys."
        },
        "synonyms": [
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "Echinococcosis of liver",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "echinococcal disease",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "hepatic echinococcosis",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "hydatid disease",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "hydatidosis",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "liver echinococcus",
                "description": ""
            },
            {
                "id": "DOID:1496",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1496",
                "name": "pulmonary echinococcosis",
                "description": ""
            }
        ],
        "id": "DOID:1496"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of digalactosylated on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3850-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3850-1"
                },
                {
                    "id": "40200705",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "In this work, the galactosylation level of serum IgG was analyzed by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) in a cohort comprising patients, including 100 diagnosed with CE, 27 with AE and 29 with HCC. The relative quantification of IgG digalactosylated (G2), monogalactosylated (G1), and agalactosylated (G0) N-glycans with the formula G0/(G1 + G2 \u00d7 2) (IgG Gal-ratio) was obtained and found to effectively distinguish between echinococcosis patients, CE and AE patients, and healthy controls, respectively. Thus, the results demonstrate that the IgG Gal-ratio has the potential to be a biomarker for diagnosis and discrimination of echinococcosis, which also needs to be verified in further studies."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3850-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3850-1"
        },
        {
            "id": "40200705",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "In this work, the galactosylation level of serum IgG was analyzed by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) in a cohort comprising patients, including 100 diagnosed with CE, 27 with AE and 29 with HCC. The relative quantification of IgG digalactosylated (G2), monogalactosylated (G1), and agalactosylated (G0) N-glycans with the formula G0/(G1 + G2 \u00d7 2) (IgG Gal-ratio) was obtained and found to effectively distinguish between echinococcosis patients, CE and AE patients, and healthy controls, respectively. Thus, the results demonstrate that the IgG Gal-ratio has the potential to be a biomarker for diagnosis and discrimination of echinococcosis, which also needs to be verified in further studies."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3850-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3850-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}