{
"biomarker_id": "BB3849-1",
"biomarker_canonical_id": "BB3849",
"condition": {
"recommended_name": {
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "ovarian cancer",
"description": "A female reproductive organ cancer that is located_in the ovary."
},
"synonyms": [
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "malignant Ovarian tumor",
"description": ""
},
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "malignant tumour of ovary",
"description": ""
},
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "ovarian neoplasm",
"description": ""
},
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "ovary neoplasm",
"description": ""
},
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "primary ovarian cancer",
"description": ""
},
{
"id": "DOID:2394",
"resource": "Disease Ontology",
"url": "https://disease-ontology.org/term/DOID:2394",
"name": "tumor of the Ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian cancer",
"description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian neoplasm",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovary neoplasm",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "tumor of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "tumour of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "cancer of ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "cancer of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant neoplasm of ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant neoplasm of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant ovarian neoplasm",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant ovarian tumor",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant ovarian tumour",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant ovary neoplasm",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant tumor of ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant tumor of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant tumour of ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "malignant tumour of the ovary",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian cancer",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian malignant tumor",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovarian malignant tumour",
"description": ""
},
{
"id": "MONDO:0008170",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008170",
"name": "ovary cancer",
"description": ""
},
{
"id": "MONDO:0011931",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011931",
"name": "ovarian cancer, susceptibility to, 1",
"description": ""
},
{
"id": "MONDO:0011931",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011931",
"name": "OVCAS1",
"description": ""
},
{
"id": "MONDO:0011931",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011931",
"name": "ovarian cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0011931",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011931",
"name": "ovarian cancer, susceptibility to, 1",
"description": ""
},
{
"id": "MIM:167000",
"resource": "MIM",
"url": "https://www.omim.org/entry/167000",
"name": "Ovarian cancer",
"description": "Ovarian cancer"
}
],
"id": "DOID:2394"
},
"biomarker_component": [
{
"biomarker": "decreased level of Le^y on immunoglobulin M",
"assessed_biomarker_entity_id": "P40259-1",
"assessed_entity_type": "protein",
"assessed_biomarker_entity": {
"recommended_name": "B-cell antigen receptor complex-associated protein beta chain",
"synonyms": [
{
"synonym": "B-cell-specific glycoprotein B29"
},
{
"synonym": "Ig-beta"
},
{
"synonym": "Immunoglobulin-associated B29 protein"
}
]
},
"specimen": [
{
"name": "blood serum",
"namespace": "UBERON",
"id": "0001977",
"url": "http://purl.obolibrary.org/obo/UBERON_0001977",
"loinc_code": ""
}
],
"evidence_source": [
{
"id": "BB3849-1",
"database": "BiomarkerKB",
"url": "https://biomarkerkb.org/biomarker/BB3849-1"
},
{
"id": "39947417",
"database": "PubMed",
"url": "",
"tags": [
"assessed_biomarker_entity_id",
" assessed_biomarker_entiy",
" assessed_entity_type",
" biomarker",
" specimen"
],
"evidence_list": [
{
"evidence": "Blood serum samples from patients (n\u00a0=\u00a0203) with ovarian cancer (OvaCan) and healthy volunteers were analyzed using a glycan microarray containing 63 immobilized glycans to determine changes in anti-glycan IgG and IgM antibody profiles in OvaCan. The AUC values for certain glycans investigated in diagnosing OvaCan indicated a fingerprint consisting of IgM antibodies to specific glycans, and the most specific anti-glycan IgM antibodies were Ley (AUC\u00a0=\u00a00.625, Se\u00a0=\u00a098.0\u00a0% and Sp\u00a0=\u00a045.0\u00a0%)."
}
]
}
]
}
],
"best_biomarker_role": [
{
"role": ""
}
],
"evidence_source": [
{
"id": "BB3849-1",
"database": "BiomarkerKB",
"url": "https://biomarkerkb.org/biomarker/BB3849-1"
},
{
"id": "39947417",
"database": "PubMed",
"url": "",
"tags": [
"condition"
],
"evidence_list": [
{
"evidence": "Blood serum samples from patients (n\u00a0=\u00a0203) with ovarian cancer (OvaCan) and healthy volunteers were analyzed using a glycan microarray containing 63 immobilized glycans to determine changes in anti-glycan IgG and IgM antibody profiles in OvaCan. The AUC values for certain glycans investigated in diagnosing OvaCan indicated a fingerprint consisting of IgM antibodies to specific glycans, and the most specific anti-glycan IgM antibodies were Ley (AUC\u00a0=\u00a00.625, Se\u00a0=\u00a098.0\u00a0% and Sp\u00a0=\u00a045.0\u00a0%)."
}
]
}
],
"crossref": [
{
"id": "BB3849-1",
"database": "BiomarkerKB",
"url": "https://biomarkerkb.org/biomarker/BB3849-1",
"categories": [
"Biomarkers"
]
}
],
"citation": [],
"section_stats": [
{
"table_id": "biomarker_component",
"table_stats": [
{
"field": "total",
"count": 1
}
],
"sort_fields": [
"biomarker",
"assessed_biomarker_entity_id",
"assessed_entity_type",
"assessed_biomarker_entity.recommended_name"
]
},
{
"table_id": "citation",
"table_stats": [
{
"field": "total",
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}
],
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}
]
}