{
    "biomarker_id": "BB3840-1",
    "biomarker_canonical_id": "BB3840",
    "condition": {
        "recommended_name": {
            "id": "DOID:0060548",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060548",
            "name": "luminal breast carcinoma A",
            "description": "A breast carcinoma that is characterized by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3."
        },
        "synonyms": [
            {
                "id": "DOID:0060548",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0060548",
                "name": "Luminal A Breast Carcinoma",
                "description": ""
            }
        ],
        "id": "DOID:0060548"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of MUCST on MUC1",
            "assessed_biomarker_entity_id": "P15941-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Mucin-1",
                "synonyms": [
                    {
                        "synonym": "Polymorphic epithelial mucin"
                    },
                    {
                        "synonym": "PEM"
                    },
                    {
                        "synonym": "Krebs von den Lungen-6"
                    },
                    {
                        "synonym": "KL-6"
                    },
                    {
                        "synonym": "Tumor-associated epithelial membrane antigen"
                    },
                    {
                        "synonym": "EMA"
                    },
                    {
                        "synonym": "Peanut-reactive urinary mucin"
                    },
                    {
                        "synonym": "PUM"
                    },
                    {
                        "synonym": "Cancer antigen 15-3"
                    },
                    {
                        "synonym": "CA 15-3"
                    },
                    {
                        "synonym": "Tumor-associated mucin"
                    },
                    {
                        "synonym": "MUC1-CT"
                    },
                    {
                        "synonym": "Breast carcinoma-associated antigen DF3"
                    },
                    {
                        "synonym": "PEMT"
                    },
                    {
                        "synonym": "Episialin"
                    },
                    {
                        "synonym": "Carcinoma-associated mucin"
                    },
                    {
                        "synonym": "H23AG"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "",
                    "namespace": "UBERON",
                    "id": "0008367",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0008367",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3840-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3840-1"
                },
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The effects of 10 \u03bcM Soyasaponin introduction on the TCGA-based luminal A network (Table 2a, Tables S9-S11) results in a 26.6% decrease in MUCST. The largest change is observed for MUCST in line with the expectations since the drug primarily targets ST3Gal1, the enzyme catalysing MUCST production. The substantial decrease in MUCST leads to an associated decrease in MUCdST by 20.7%."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3840-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3840-1"
        },
        {
            "id": "40492697",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The effects of 10 \u03bcM Soyasaponin introduction on the TCGA-based luminal A network (Table 2a, Tables S9-S11) results in a 26.6% decrease in MUCST. The largest change is observed for MUCST in line with the expectations since the drug primarily targets ST3Gal1, the enzyme catalysing MUCST production. The substantial decrease in MUCST leads to an associated decrease in MUCdST by 20.7%."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3840-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3840-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}