{
    "biomarker_id": "BB3838-1",
    "biomarker_canonical_id": "BB3838",
    "condition": {
        "recommended_name": {
            "id": "DOID:0060548",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060548",
            "name": "luminal breast carcinoma A",
            "description": "A breast carcinoma that is characterized by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3."
        },
        "synonyms": [
            {
                "id": "DOID:0060548",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0060548",
                "name": "Luminal A Breast Carcinoma",
                "description": ""
            }
        ],
        "id": "DOID:0060548"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of MUCST on MUC1",
            "assessed_biomarker_entity_id": "P15941-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Mucin-1",
                "synonyms": [
                    {
                        "synonym": "Polymorphic epithelial mucin"
                    },
                    {
                        "synonym": "PEM"
                    },
                    {
                        "synonym": "Krebs von den Lungen-6"
                    },
                    {
                        "synonym": "KL-6"
                    },
                    {
                        "synonym": "Tumor-associated epithelial membrane antigen"
                    },
                    {
                        "synonym": "EMA"
                    },
                    {
                        "synonym": "Peanut-reactive urinary mucin"
                    },
                    {
                        "synonym": "PUM"
                    },
                    {
                        "synonym": "Cancer antigen 15-3"
                    },
                    {
                        "synonym": "CA 15-3"
                    },
                    {
                        "synonym": "Tumor-associated mucin"
                    },
                    {
                        "synonym": "MUC1-CT"
                    },
                    {
                        "synonym": "Breast carcinoma-associated antigen DF3"
                    },
                    {
                        "synonym": "PEMT"
                    },
                    {
                        "synonym": "Episialin"
                    },
                    {
                        "synonym": "Carcinoma-associated mucin"
                    },
                    {
                        "synonym": "H23AG"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "",
                    "namespace": "UBERON",
                    "id": "0008367",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0008367",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3838-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3838-1"
                },
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The results for core 2, and the four sialylated epitopes (Table 1a, Table S6) show a significant upregulation in MUC6St and MUCdST concentrations and smaller upregulation in MUCST concentration at 80 h. This indicates a clear shift towards tumour-associated core 1-glycan biosynthesis in luminal A breast cancer compared to MUC1 in healthy breast epithelial tissue. The network demonstrates a 32% upregulation of MUCST, which, albeit significant, is smaller than the values for the MUC6ST and MUCdST, ranging between 55%\u201370%. This can be attributed to the simultaneous overexpression of ST3GAL1 and ST6GALNAC2. Although the increased ST3GAL1 activity brings about an enhanced rate in MUCST synthesis, this is counteracted by the increased enzyme activity of ST6GALNAC2 partaking in two reactions. The first reaction, denoted by ST6GALNAC2_a catalyses the \u03b12,6 sialylation of the MUC1 T-antigen GalNAc residue, thereby limiting the amount of MUC1 T-antigen available for \u03b1-2,3-Sialylation at the Gal residue. The second reaction, denoted by ST6GALNAC2_b, catalyses the \u03b12,6 sialylation of the GalNAc residue on MUCST, hence resulting in MUCST consumption. Nevertheless, a 32% upregulation of MUCST in luminal A breast cancer is substantial enough to investigate the influence of increased MUCST binding on the CXCL5 synthesis pathway in monocyte-derived macrophages."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3838-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3838-1"
        },
        {
            "id": "40492697",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The results for core 2, and the four sialylated epitopes (Table 1a, Table S6) show a significant upregulation in MUC6St and MUCdST concentrations and smaller upregulation in MUCST concentration at 80 h. This indicates a clear shift towards tumour-associated core 1-glycan biosynthesis in luminal A breast cancer compared to MUC1 in healthy breast epithelial tissue. The network demonstrates a 32% upregulation of MUCST, which, albeit significant, is smaller than the values for the MUC6ST and MUCdST, ranging between 55%\u201370%. This can be attributed to the simultaneous overexpression of ST3GAL1 and ST6GALNAC2. Although the increased ST3GAL1 activity brings about an enhanced rate in MUCST synthesis, this is counteracted by the increased enzyme activity of ST6GALNAC2 partaking in two reactions. The first reaction, denoted by ST6GALNAC2_a catalyses the \u03b12,6 sialylation of the MUC1 T-antigen GalNAc residue, thereby limiting the amount of MUC1 T-antigen available for \u03b1-2,3-Sialylation at the Gal residue. The second reaction, denoted by ST6GALNAC2_b, catalyses the \u03b12,6 sialylation of the GalNAc residue on MUCST, hence resulting in MUCST consumption. Nevertheless, a 32% upregulation of MUCST in luminal A breast cancer is substantial enough to investigate the influence of increased MUCST binding on the CXCL5 synthesis pathway in monocyte-derived macrophages."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3838-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3838-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}