{
    "biomarker_id": "BB3826-2",
    "biomarker_canonical_id": "BB3826",
    "condition": {
        "recommended_name": {
            "id": "DOID:3908",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3908",
            "name": "lung non-small cell carcinoma",
            "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma."
        },
        "synonyms": [
            {
                "id": "DOID:3908",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3908",
                "name": "NSCLC",
                "description": ""
            },
            {
                "id": "DOID:3908",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3908",
                "name": "Non-small cell lung cancer",
                "description": ""
            },
            {
                "id": "DOID:3908",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3908",
                "name": "non-small cell lung carcinoma",
                "description": ""
            }
        ],
        "id": "DOID:3908"
    },
    "biomarker_component": [
        {
            "biomarker": "increased level of TnMUC1 on MUC1",
            "assessed_biomarker_entity_id": "P15941-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Mucin-1",
                "synonyms": [
                    {
                        "synonym": "Polymorphic epithelial mucin"
                    },
                    {
                        "synonym": "PEM"
                    },
                    {
                        "synonym": "Krebs von den Lungen-6"
                    },
                    {
                        "synonym": "KL-6"
                    },
                    {
                        "synonym": "Tumor-associated epithelial membrane antigen"
                    },
                    {
                        "synonym": "EMA"
                    },
                    {
                        "synonym": "Peanut-reactive urinary mucin"
                    },
                    {
                        "synonym": "PUM"
                    },
                    {
                        "synonym": "Cancer antigen 15-3"
                    },
                    {
                        "synonym": "CA 15-3"
                    },
                    {
                        "synonym": "Tumor-associated mucin"
                    },
                    {
                        "synonym": "MUC1-CT"
                    },
                    {
                        "synonym": "Breast carcinoma-associated antigen DF3"
                    },
                    {
                        "synonym": "PEMT"
                    },
                    {
                        "synonym": "Episialin"
                    },
                    {
                        "synonym": "Carcinoma-associated mucin"
                    },
                    {
                        "synonym": "H23AG"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "tissue",
                    "namespace": "UBERON",
                    "id": "0000479",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000479",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3826-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3826-2"
                },
                {
                    "id": "40562040",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "EGFR TKI exposure resulted in a more than 2-fold increase in TnMUC1 cell surface expression compared with untreated controls (Figures 3O, S7D, and S7E). Quantitative IHC scoring revealed a 3-fold elevation in TnMUC1 protein levels following EGFR TKI administration (Figures 3P, 3Q, S4D, and S4E). IHC analysis of the subcutaneous tumors revealed that both itraconazole and osimertinib downregulated C1GALT1 expression and upregulated TnMUC1 expression."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3826-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3826-2"
        },
        {
            "id": "40562040",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "EGFR TKI exposure resulted in a more than 2-fold increase in TnMUC1 cell surface expression compared with untreated controls (Figures 3O, S7D, and S7E). Quantitative IHC scoring revealed a 3-fold elevation in TnMUC1 protein levels following EGFR TKI administration (Figures 3P, 3Q, S4D, and S4E). IHC analysis of the subcutaneous tumors revealed that both itraconazole and osimertinib downregulated C1GALT1 expression and upregulated TnMUC1 expression."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3826-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3826-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}