{
    "biomarker_id": "BB1520-1",
    "biomarker_canonical_id": "BB1520",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased MB level",
            "assessed_biomarker_entity_id": "P02144-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Myoglobin",
                "synonyms": [
                    {
                        "synonym": "Pseudoperoxidase MB"
                    },
                    {
                        "synonym": "1.11.1.-"
                    },
                    {
                        "synonym": "Nitrite reductase MB"
                    },
                    {
                        "synonym": "1.7.-.-"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "20569-0"
                }
            ],
            "evidence_source": [
                {
                    "id": "BB1520-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB1520-1"
                },
                {
                    "id": "32596365",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32596365",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The levels of laboratory cardiac markers, lactose dehydrogenase (LDH), creatine kinase (CK), creatinine kinase-muscle/brain activity (CK-MB), myoglobin (Mb), cardiac troponin I (cTnI), alpha-hydroxybutyrate dehydrogenase (\u03b1-HBDH), aspartate aminotransferase (AST), and N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) increase in different proportions in patients with COVID-19 (see Table 1)."
                        }
                    ]
                },
                {
                    "id": "32450473",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32450473",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "An increased concentration of myoglobin was associated with an increased risk of hospitalization mortality in non-survivors with NCIP. In conclusion, our study provides important documentation that in this single-center, an elevated serum concentration of myoglobin (>/=306.5 ug/L) is associated with an increased risk of hospitalization mortality in non-survivor with NCIP, independent of elevation in CK-MB and Troponin I levels."
                        }
                    ]
                },
                {
                    "id": "32305557",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32305557",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The severity of COVID-19 is associated with acute cardiac injury, and acute cardiac injury is associated with death. Cardiac injury biomarkers mainly increase in non-survivors. This highlights the need to effectively monitor heart health to prevent myocarditis in patients infected with COVID-19."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "BB1520-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB1520-1"
        },
        {
            "id": "32596365",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32596365",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The levels of laboratory cardiac markers, lactose dehydrogenase (LDH), creatine kinase (CK), creatinine kinase-muscle/brain activity (CK-MB), myoglobin (Mb), cardiac troponin I (cTnI), alpha-hydroxybutyrate dehydrogenase (\u03b1-HBDH), aspartate aminotransferase (AST), and N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) increase in different proportions in patients with COVID-19 (see Table 1)."
                }
            ]
        },
        {
            "id": "32450473",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32450473",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "An increased concentration of myoglobin was associated with an increased risk of hospitalization mortality in non-survivors with NCIP. In conclusion, our study provides important documentation that in this single-center, an elevated serum concentration of myoglobin (>/=306.5 ug/L) is associated with an increased risk of hospitalization mortality in non-survivor with NCIP, independent of elevation in CK-MB and Troponin I levels."
                }
            ]
        },
        {
            "id": "32305557",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32305557",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The severity of COVID-19 is associated with acute cardiac injury, and acute cardiac injury is associated with death. Cardiac injury biomarkers mainly increase in non-survivors. This highlights the need to effectively monitor heart health to prevent myocarditis in patients infected with COVID-19."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB1520-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB1520-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019.",
            "journal": "BioMed research international",
            "authors": "Li Lin, Zhou Qi, Xu Jiancheng",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32596365",
                    "url": "https://glygen.org/publication/PubMed/32596365"
                }
            ],
            "evidence": [
                {
                    "id": "AN6751-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB1520-1"
                }
            ]
        },
        {
            "title": "Elevated cardiac biomarkers are associated with increased mortality for inpatients with COVID-19: A retrospective case-control study.",
            "journal": "Journal of clinical anesthesia",
            "authors": "Su M, Wang Y, Peng J, Wu MJ, Deng W, Yang YS",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32450473",
                    "url": "https://glygen.org/publication/PubMed/32450473"
                }
            ],
            "evidence": [
                {
                    "id": "BB1520-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB1520-1"
                }
            ]
        },
        {
            "title": "The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis.",
            "journal": "Progress in cardiovascular diseases",
            "authors": "Li JW, Han TW, Woodward M, Anderson CS, Zhou H, Chen YD, Neal B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32305557",
                    "url": "https://glygen.org/publication/PubMed/32305557"
                }
            ],
            "evidence": [
                {
                    "id": "BB1520-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB1520-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 3
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}