{
    "biomarker_id": "AN6747-1",
    "biomarker_canonical_id": "AN6747",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
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                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased PCT level",
            "assessed_biomarker_entity_id": "P01258-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Calcitonin",
                "synonyms": [
                    {
                        "synonym": "Calcitonin carboxyl-terminal peptide"
                    },
                    {
                        "synonym": "CCP"
                    },
                    {
                        "synonym": "PDN-21"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6747-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6747-1"
                },
                {
                    "id": "32505227",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32505227",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen",
                        ""
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Other consistently reported markers in non-survivors are increased procalcitonin (PCT) and IL-6 levels, as well as increased serum urea, creatinine, cystatin C, direct bilirubin, and cholinesterase."
                        }
                    ]
                },
                {
                    "id": "32589600",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32589600",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen",
                        ""
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Many biomarkers have been associated with poor outcomes and represent a candidate for risk stratification models for predicting severe COVID-19 in order to guide clinical care. Among all, lymphopenia, thrombocytopenia, leucocytosis, CRP, PCT, LDH, AST, ALT, D-dimer, cTn represent the most predictive parameters of severe COVID-19"
                        }
                    ]
                },
                {
                    "id": "32766546",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32766546",
                    "tags": [
                        "",
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "On multivariable analysis, the risk factors found to be significantly associated with admission to intensive care were age above 50 years old, a qSOFA score above 0, smoking, elevated CRP and elevated procalcitonin levels. Asthma, smoking and elevated procalcitonin levels correlated significantly with mortality in our cohort."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6747-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6747-1"
        },
        {
            "id": "32505227",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32505227",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Other consistently reported markers in non-survivors are increased procalcitonin (PCT) and IL-6 levels, as well as increased serum urea, creatinine, cystatin C, direct bilirubin, and cholinesterase."
                }
            ]
        },
        {
            "id": "32589600",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32589600",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Many biomarkers have been associated with poor outcomes and represent a candidate for risk stratification models for predicting severe COVID-19 in order to guide clinical care. Among all, lymphopenia, thrombocytopenia, leucocytosis, CRP, PCT, LDH, AST, ALT, D-dimer, cTn represent the most predictive parameters of severe COVID-19"
                }
            ]
        },
        {
            "id": "32766546",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32766546",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "On multivariable analysis, the risk factors found to be significantly associated with admission to intensive care were age above 50 years old, a qSOFA score above 0, smoking, elevated CRP and elevated procalcitonin levels. Asthma, smoking and elevated procalcitonin levels correlated significantly with mortality in our cohort."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6747-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6747-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Immunology of COVID-19: Current State of the Science.",
            "journal": "Immunity",
            "authors": "Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salome B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gumus ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32505227",
                    "url": "https://glygen.org/publication/PubMed/32505227"
                }
            ],
            "evidence": [
                {
                    "id": "AN6338-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6747-1"
                }
            ]
        },
        {
            "title": "Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19).",
            "journal": "Diagnosis (Berlin, Germany)",
            "authors": "Ciaccio Marcello, Agnello Luisa",
            "date": "2020-11-18",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32589600",
                    "url": "https://glygen.org/publication/PubMed/32589600"
                }
            ],
            "evidence": [
                {
                    "id": "AN6747-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6747-1"
                }
            ]
        },
        {
            "title": "Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait.",
            "journal": "EClinicalMedicine",
            "authors": "Almazeedi Sulaiman, Al-Youha Sarah, Jamal Mohammad H, Al-Haddad Mohannad, Al-Muhaini Ali, Al-Ghimlas Fahad, Al-Sabah Salman",
            "date": "2020-07",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32766546",
                    "url": "https://glygen.org/publication/PubMed/32766546"
                }
            ],
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6747-1"
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        }
    ],
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