{
    "biomarker_id": "AN6735-1",
    "biomarker_canonical_id": "AN6735",
    "condition": {
        "recommended_name": {
            "id": "DOID:3571",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3571",
            "name": "liver cancer",
            "description": "A hepatobiliary system cancer that is located_in the liver."
        },
        "synonyms": [
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Ca liver - primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Resectable malignant neoplasm of Liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant hepato-biliary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant tumor of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "non-resectable primary hepatic malignant neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary liver cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "resectable malignant neoplasm of the liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, not specified as primary or secondary",
                "description": ""
            }
        ],
        "id": "DOID:3571"
    },
    "biomarker_component": [
        {
            "biomarker": "increased N-glycan level",
            "assessed_biomarker_entity_id": "G85767HW",
            "assessed_entity_type": "glycan",
            "assessed_biomarker_entity": {
                "recommended_name": "Biantennary bisected core fucosylated N-glycan",
                "synonyms": []
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6735-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6735-1"
                },
                {
                    "id": "33255418",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33255418",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The level of serum N-glycan A2G1(6)FB, a biantennary N-glycan containing core fucose and bisecting GlcNAc residues, was significantly higher in hepatitis C virus (HCV)-infected cirrhotic patients with HCC than in those without HCC. In addition, A2G1(6)FB was detectable in HCV-infected patients with early-stage HCC. In conclusion, the N-glycan A2G1(6)FB may be a potential biomarker to detect early HCC development in HCV-infected patients."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6735-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6735-1"
        },
        {
            "id": "33255418",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33255418",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The level of serum N-glycan A2G1(6)FB, a biantennary N-glycan containing core fucose and bisecting GlcNAc residues, was significantly higher in hepatitis C virus (HCV)-infected cirrhotic patients with HCC than in those without HCC. In addition, A2G1(6)FB was detectable in HCV-infected patients with early-stage HCC. In conclusion, the N-glycan A2G1(6)FB may be a potential biomarker to detect early HCC development in HCV-infected patients."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6735-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6735-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "A Potential Serum N-glycan Biomarker for Hepatitis C Virus-Related Early-Stage Hepatocellular Carcinoma with Liver Cirrhosis.",
            "journal": "International journal of molecular sciences",
            "authors": "Higashi M, Yoshimura T, Usui N, Kano Y, Deguchi A, Tanabe K, Uchimura Y, Kuriyama S, Suzuki Y, Masaki T, Ikenaka K",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33255418",
                    "url": "https://glygen.org/publication/PubMed/33255418"
                }
            ],
            "evidence": [
                {
                    "id": "AN6734-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6735-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}