{
    "biomarker_id": "AN6696-1",
    "biomarker_canonical_id": "AN6696",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased SORBS2 level",
            "assessed_biomarker_entity_id": "O94875-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Sorbin and SH3 domain-containing protein 2",
                "synonyms": [
                    {
                        "synonym": "Arg-binding protein 2"
                    },
                    {
                        "synonym": "ArgBP2"
                    },
                    {
                        "synonym": "Arg/Abl-interacting protein 2"
                    },
                    {
                        "synonym": "Sorbin"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6696-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6696-1"
                },
                {
                    "id": "33311452",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33311452",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "There was significantly lower expression of SORBS2 protein in metastatic tissues than that in primary tissues and normal tissues. Kaplan\u201a\u00c4\u00ecMeier survival analysis indicated that patients with low SORBS2 had a poorer overall survival than those belonging to high SORBS2 levels in ccRCC."
                        }
                    ]
                },
                {
                    "id": "32905431",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32905431",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "KCNQ1OT1 and SORBS2 were elevated in DN. Both knockdown of KCNQ1OT1 and silencing of SORBS2 restrained proliferation and fibrosis and induced apoptosis in diabetic nephropathy (DN) cells."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6696-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6696-1"
        },
        {
            "id": "33311452",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33311452",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "There was significantly lower expression of SORBS2 protein in metastatic tissues than that in primary tissues and normal tissues. Kaplan\u201a\u00c4\u00ecMeier survival analysis indicated that patients with low SORBS2 had a poorer overall survival than those belonging to high SORBS2 levels in ccRCC."
                }
            ]
        },
        {
            "id": "32905431",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32905431",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "KCNQ1OT1 and SORBS2 were elevated in DN. Both knockdown of KCNQ1OT1 and silencing of SORBS2 restrained proliferation and fibrosis and induced apoptosis in diabetic nephropathy (DN) cells."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6696-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6696-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.",
            "journal": "Cell death & disease",
            "authors": "Lv Q, Dong F, Zhou Y, Cai Z, Wang G",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33311452",
                    "url": "https://glygen.org/publication/PubMed/33311452"
                }
            ],
            "evidence": [
                {
                    "id": "AN6695-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6696-1"
                }
            ]
        },
        {
            "title": "LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-kB pathway in diabetic nephropathy.",
            "journal": "Diabetology & metabolic syndrome",
            "authors": "Jie R, Zhu P, Zhong J, Zhang Y, Wu H",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32905431",
                    "url": "https://glygen.org/publication/PubMed/32905431"
                }
            ],
            "evidence": [
                {
                    "id": "AN6696-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6696-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
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                    "count": 1
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            ],
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                "assessed_biomarker_entity_id",
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                "assessed_biomarker_entity.recommended_name"
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        },
        {
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}