{
    "biomarker_id": "AN6694-1",
    "biomarker_canonical_id": "AN6694",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased SCARB1 level",
            "assessed_biomarker_entity_id": "Q8WTV0-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Scavenger receptor class B member 1",
                "synonyms": [
                    {
                        "synonym": "CD36 and LIMPII analogous 1"
                    },
                    {
                        "synonym": "CLA-1"
                    },
                    {
                        "synonym": "CD36 antigen-like 1"
                    },
                    {
                        "synonym": "Collagen type I receptor, thrombospondin receptor-like 1"
                    },
                    {
                        "synonym": "SR-BI"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6694-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6694-1"
                },
                {
                    "id": "29357836",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29357836",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The expression of SR-BI was significantly increased in ccRCC tissues compared with normal matched tissues. Patients with tumors that expressed high levels of SR-BI had a shorter PFS survival (P = 0.0062)."
                        }
                    ]
                },
                {
                    "id": "26936883",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26936883",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Our findings demonstrate that hSR-BII, and to a lesser extent hSR-BI, significantly increase LPS-induced inflammation and contribute to LPS-induced tissue injury in the liver and kidney, two major organs susceptible to LPS toxicity."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6694-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6694-1"
        },
        {
            "id": "29357836",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29357836",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The expression of SR-BI was significantly increased in ccRCC tissues compared with normal matched tissues. Patients with tumors that expressed high levels of SR-BI had a shorter PFS survival (P = 0.0062)."
                }
            ]
        },
        {
            "id": "26936883",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26936883",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Our findings demonstrate that hSR-BII, and to a lesser extent hSR-BI, significantly increase LPS-induced inflammation and contribute to LPS-induced tissue injury in the liver and kidney, two major organs susceptible to LPS toxicity."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6694-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6694-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma.",
            "journal": "BMC cancer",
            "authors": "Xu GH, Lou N, Shi HC, Xu YC, Ruan HL, Xiao W, Liu L, Li X, Xiao HB, Qiu B, Bao L, Yuan CF, Zhou YL, Hu WJ, Chen K, Yang HM, Zhang XP",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29357836",
                    "url": "https://glygen.org/publication/PubMed/29357836"
                }
            ],
            "evidence": [
                {
                    "id": "AN6693-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6694-1"
                }
            ]
        },
        {
            "title": "Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice.",
            "journal": "Journal of immunology (Baltimore, Md. : 1950)",
            "authors": "Baranova IN, Souza AC, Bocharov AV, Vishnyakova TG, Hu X, Vaisman BL, Amar MJ, Chen Z, Kost Y, Remaley AT, Patterson AP, Yuen PS, Star RA, Eggerman TL",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26936883",
                    "url": "https://glygen.org/publication/PubMed/26936883"
                }
            ],
            "evidence": [
                {
                    "id": "AN6694-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6694-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
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                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
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        }
    ]
}