{
    "biomarker_id": "AN6682-1",
    "biomarker_canonical_id": "AN6682",
    "condition": {
        "recommended_name": {
            "id": "DOID:363",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:363",
            "name": "uterine cancer",
            "description": "A female reproductive organ cancer that is located_in the uterus."
        },
        "synonyms": [
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "CA - cancer of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "Tumour of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterus neoplasm",
                "description": ""
            }
        ],
        "id": "DOID:363"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CD10 level",
            "assessed_biomarker_entity_id": "P08473-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Neprilysin",
                "synonyms": [
                    {
                        "synonym": "Neutral endopeptidase 24.11"
                    },
                    {
                        "synonym": "NEP"
                    },
                    {
                        "synonym": "Neutral endopeptidase"
                    },
                    {
                        "synonym": "Skin fibroblast elastase"
                    },
                    {
                        "synonym": "SFE"
                    },
                    {
                        "synonym": "Common acute lymphocytic leukemia antigen"
                    },
                    {
                        "synonym": "CALLA"
                    },
                    {
                        "synonym": "Enkephalinase"
                    },
                    {
                        "synonym": "Atriopeptidase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "uterus",
                    "namespace": "UBERON",
                    "id": "0000995",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000995",
                    "loinc_code": "51214-5"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6682-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6682-1"
                },
                {
                    "id": "15571618",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15571618",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Uterine Adenosarcoma (UAS) with sarcomatous overgrowth stained strongly positive in five of eight (63%) cases. Pattern of strong positivity was focal in four of five (80%). These findings suggest that CD10 can be used to differentiate UAS from cellular leiomyoma, or in case endometrial stromal cells exhibit muscle differentiation. Furthermore, CD10 positivity in recurrent UAS might guide the pathologist toward an endometrial stromal origin."
                        }
                    ]
                },
                {
                    "id": "11532038",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/11532038",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "CD10 is a reliable and sensitive immunohistochemical marker of normal endometrial stroma. Positivity, which is often strong and/or diffuse is found in endometrial stromal nodules and low-grade ESS. Positive staining with CD10, when strong and diffuse, may be useful in distinguishing these tumours from histological mimics, especially cellular leiomyoma and AGCT which are generally negative. There was positive staining of all low-grade Endometrial stromal sarcoma (ESS)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6682-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6682-1"
        },
        {
            "id": "15571618",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15571618",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Uterine Adenosarcoma (UAS) with sarcomatous overgrowth stained strongly positive in five of eight (63%) cases. Pattern of strong positivity was focal in four of five (80%). These findings suggest that CD10 can be used to differentiate UAS from cellular leiomyoma, or in case endometrial stromal cells exhibit muscle differentiation. Furthermore, CD10 positivity in recurrent UAS might guide the pathologist toward an endometrial stromal origin."
                }
            ]
        },
        {
            "id": "11532038",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/11532038",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "CD10 is a reliable and sensitive immunohistochemical marker of normal endometrial stroma. Positivity, which is often strong and/or diffuse is found in endometrial stromal nodules and low-grade ESS. Positive staining with CD10, when strong and diffuse, may be useful in distinguishing these tumours from histological mimics, especially cellular leiomyoma and AGCT which are generally negative. There was positive staining of all low-grade Endometrial stromal sarcoma (ESS)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6682-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6682-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.",
            "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
            "authors": "Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I",
            "date": "2004",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15571618",
                    "url": "https://glygen.org/publication/PubMed/15571618"
                }
            ],
            "evidence": [
                {
                    "id": "AN6681-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6682-1"
                }
            ]
        },
        {
            "title": "CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms.",
            "journal": "Histopathology",
            "authors": "McCluggage WG, Sumathi VP, Maxwell P",
            "date": "2001",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11532038",
                    "url": "https://glygen.org/publication/PubMed/11532038"
                }
            ],
            "evidence": [
                {
                    "id": "AN6682-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6682-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
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        }
    ]
}