{
    "biomarker_id": "AN6676-1",
    "biomarker_canonical_id": "AN6676",
    "condition": {
        "recommended_name": {
            "id": "DOID:363",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:363",
            "name": "uterine cancer",
            "description": "A female reproductive organ cancer that is located_in the uterus."
        },
        "synonyms": [
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "CA - cancer of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "Tumour of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterus neoplasm",
                "description": ""
            }
        ],
        "id": "DOID:363"
    },
    "biomarker_component": [
        {
            "biomarker": "increased COX-2 level",
            "assessed_biomarker_entity_id": "P35354-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Prostaglandin G/H synthase 2",
                "synonyms": [
                    {
                        "synonym": "Cyclooxygenase-2"
                    },
                    {
                        "synonym": "COX-2"
                    },
                    {
                        "synonym": "Prostaglandin H2 synthase 2"
                    },
                    {
                        "synonym": "PGH synthase 2"
                    },
                    {
                        "synonym": "PGHS-2"
                    },
                    {
                        "synonym": "Prostaglandin-endoperoxide synthase 2"
                    },
                    {
                        "synonym": "PHS II"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "uterus",
                    "namespace": "UBERON",
                    "id": "0000995",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000995",
                    "loinc_code": "49476-5"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6676-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6676-1"
                },
                {
                    "id": "15589595",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15589595",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "COX-2 overexpression was noted in one third of the cases in both early and advanced stage disease. These patients fared significantly worse than those without COX-2 overexpression."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6676-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6676-1"
        },
        {
            "id": "15589595",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15589595",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "COX-2 overexpression was noted in one third of the cases in both early and advanced stage disease. These patients fared significantly worse than those without COX-2 overexpression."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6676-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6676-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies?",
            "journal": "Gynecologic oncology",
            "authors": "Raspollini MR, Susini T, Amunni G, Paglierani M, Taddei A, Marchionni M, Scarselli G, Taddei GL",
            "date": "2005",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15589595",
                    "url": "https://glygen.org/publication/PubMed/15589595"
                }
            ],
            "evidence": [
                {
                    "id": "AN6673-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6676-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}