{
    "biomarker_id": "AN6665-1",
    "biomarker_canonical_id": "AN6665",
    "condition": {
        "recommended_name": {
            "id": "DOID:363",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:363",
            "name": "uterine cancer",
            "description": "A female reproductive organ cancer that is located_in the uterus."
        },
        "synonyms": [
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "CA - cancer of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "Tumour of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterus neoplasm",
                "description": ""
            }
        ],
        "id": "DOID:363"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased P2RX7 level",
            "assessed_biomarker_entity_id": "Q99572-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "P2X purinoceptor 7",
                "synonyms": [
                    {
                        "synonym": "Purinergic receptor"
                    },
                    {
                        "synonym": "P2Z receptor"
                    },
                    {
                        "synonym": "ATP receptor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "uterus",
                    "namespace": "UBERON",
                    "id": "0000995",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000995",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6665-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6665-1"
                },
                {
                    "id": "17035398",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/17035398",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The P2X7 is expressed predominantly in the epithelial components of the uterus, (a) Levels of the P2X(7) are lower in uterine epithelial cancer tissues than in the corresponding normal tissues. (b) The data suggest that tissue P2X(7) mRNA and protein levels could be used as a novel biomarker to differentiate normal and cancer uterine epithelial tissues. Uterine epithelial cancerous lesions lack expression of the P2X7."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6665-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6665-1"
        },
        {
            "id": "17035398",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/17035398",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The P2X7 is expressed predominantly in the epithelial components of the uterus, (a) Levels of the P2X(7) are lower in uterine epithelial cancer tissues than in the corresponding normal tissues. (b) The data suggest that tissue P2X(7) mRNA and protein levels could be used as a novel biomarker to differentiate normal and cancer uterine epithelial tissues. Uterine epithelial cancerous lesions lack expression of the P2X7."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6665-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6665-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The P2X7 receptor: a novel biomarker of uterine epithelial cancers.",
            "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology",
            "authors": "Li X, Zhou L, Feng YH, Abdul-Karim FW, Gorodeski GI",
            "date": "2006",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17035398",
                    "url": "https://glygen.org/publication/PubMed/17035398"
                }
            ],
            "evidence": [
                {
                    "id": "AN6662-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6665-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}