{
    "biomarker_id": "AN6662-1",
    "biomarker_canonical_id": "AN6662",
    "condition": {
        "recommended_name": {
            "id": "DOID:363",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:363",
            "name": "uterine cancer",
            "description": "A female reproductive organ cancer that is located_in the uterus."
        },
        "synonyms": [
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "CA - cancer of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "Tumour of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterus neoplasm",
                "description": ""
            }
        ],
        "id": "DOID:363"
    },
    "biomarker_component": [
        {
            "biomarker": "increased RCAS1 level",
            "assessed_biomarker_entity_id": "O00559-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Receptor-binding cancer antigen expressed on SiSo cells",
                "synonyms": [
                    {
                        "synonym": "Estrogen receptor-binding fragment-associated gene 9 protein"
                    },
                    {
                        "synonym": "Cancer-associated surface antigen RCAS1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6662-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6662-1"
                },
                {
                    "id": "16842844",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/16842844",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Uterine cancer patients had significantly higher serum RCAS1 concentrations than did healthy women. The RCAS1 level was dramatically reduced in patients who had a positive response to treatment; however, the RCAS1 value increased in patients whose tumors clearly grew (P= 0.0007 and P= 0.0008, respectively) (Fig. 3)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6662-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6662-1"
        },
        {
            "id": "16842844",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/16842844",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Uterine cancer patients had significantly higher serum RCAS1 concentrations than did healthy women. The RCAS1 level was dramatically reduced in patients who had a positive response to treatment; however, the RCAS1 value increased in patients whose tumors clearly grew (P= 0.0007 and P= 0.0008, respectively) (Fig. 3)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6662-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6662-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Clinical significance of RCAS1 as a biomarker of uterine cancer.",
            "journal": "Gynecologic oncology",
            "authors": "Sonoda K, Miyamoto S, Hirakawa T, Yagi H, Yotsumoto F, Nakashima M, Watanabe T, Nakano H",
            "date": "2006",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16842844",
                    "url": "https://glygen.org/publication/PubMed/16842844"
                }
            ],
            "evidence": [
                {
                    "id": "AN6661-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6662-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}