{
    "biomarker_id": "AN6661-1",
    "biomarker_canonical_id": "AN6661",
    "condition": {
        "recommended_name": {
            "id": "DOID:10534",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:10534",
            "name": "stomach cancer",
            "description": "A gastrointestinal system cancer that is located_in the stomach."
        },
        "synonyms": [
            {
                "id": "DOID:10534",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10534",
                "name": "gastric cancer",
                "description": ""
            },
            {
                "id": "DOID:10534",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10534",
                "name": "gastric neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "gastric cancer",
                "description": "A primary or metastatic malignant neoplasm involving the stomach."
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "gastric neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "Ca lesser curvature - stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "GC",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "cancer of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "gastric cancer",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "gastric cancer risk after h. pylori infection",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "gastric cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant gastric neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant gastric tumor",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant gastric tumour",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant neoplasm of lesser curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant neoplasm of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant neoplasm of the stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant stomach neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of body of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of greater curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of lesser curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of the stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumour of body of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumour of greater curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumour of lesser curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumour of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumour of the stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "stomach cancer",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "Ca body - stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "ca greater curvature of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant neoplasm of body of stomach",
                "description": ""
            },
            {
                "id": "MIM:613659",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/613659",
                "name": "Gastric cancer",
                "description": "Gastric cancer"
            }
        ],
        "id": "DOID:10534"
    },
    "biomarker_component": [
        {
            "biomarker": "increased ERBB2 level",
            "assessed_biomarker_entity_id": "P04626-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Receptor tyrosine-protein kinase erbB-2",
                "synonyms": [
                    {
                        "synonym": "Metastatic lymph node gene 19 protein"
                    },
                    {
                        "synonym": "MLN 19"
                    },
                    {
                        "synonym": "Tyrosine kinase-type cell surface receptor HER2"
                    },
                    {
                        "synonym": "p185erbB2"
                    },
                    {
                        "synonym": "Proto-oncogene Neu"
                    },
                    {
                        "synonym": "Proto-oncogene c-ErbB-2"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "stomach",
                    "namespace": "UBERON",
                    "id": "0000945",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000945",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6661-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6661-1"
                },
                {
                    "id": "10829039",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/10829039",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Kaplan-Meier analysis (log-rank statistics) revealed a significant association of increasing expression of c-erbB-2 with shorter disease-free (P =. 0023) and overall survival (P =.0160). High amounts of p185 were significantly associated with a high expression of urokinase-type plasminogen activator (uPA) (P <.010), uPA-receptor (P =.030), type-1 plasminogen activator inhibitor (PAI) (P <.010), type-2 PAI (P =.021), cathepsin D (P =.036), matrix metalloproteinase-2 (P =. 024), alpha-1-antichymotrypsin (P =.025), and alpha-2-macroglobulin (P =.017). Multivariate analysis considering these proteases/protease inhibitors, in addition to alpha-1-antitrypsin, tissue plasminogen activator, plasminogen, alpha-2-antiplasmin, and antithrombin III, and established prognostic parameters revealed that, in addition to surgical curability, pT stage, pN stage, and PAI-1, c-erbB-2 is an independent prognostic factor for overall survival of curatively resected patients (n = 139; P =.049; relative risk, 1.54; 95% confidence interval, 1.08 to 1.67) and all patients (P =.028; relative risk 1.33; 95% CI, 1.28 to 1.38)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6661-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6661-1"
        },
        {
            "id": "10829039",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/10829039",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Kaplan-Meier analysis (log-rank statistics) revealed a significant association of increasing expression of c-erbB-2 with shorter disease-free (P =. 0023) and overall survival (P =.0160). High amounts of p185 were significantly associated with a high expression of urokinase-type plasminogen activator (uPA) (P <.010), uPA-receptor (P =.030), type-1 plasminogen activator inhibitor (PAI) (P <.010), type-2 PAI (P =.021), cathepsin D (P =.036), matrix metalloproteinase-2 (P =. 024), alpha-1-antichymotrypsin (P =.025), and alpha-2-macroglobulin (P =.017). Multivariate analysis considering these proteases/protease inhibitors, in addition to alpha-1-antitrypsin, tissue plasminogen activator, plasminogen, alpha-2-antiplasmin, and antithrombin III, and established prognostic parameters revealed that, in addition to surgical curability, pT stage, pN stage, and PAI-1, c-erbB-2 is an independent prognostic factor for overall survival of curatively resected patients (n = 139; P =.049; relative risk, 1.54; 95% confidence interval, 1.08 to 1.67) and all patients (P =.028; relative risk 1.33; 95% CI, 1.28 to 1.38)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6661-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6661-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems.",
            "journal": "Journal of clinical oncology : official journal of the American Society of Clinical Oncology",
            "authors": "Allgayer H, Babic R, Gruetzner KU, Tarabichi A, Schildberg FW, Heiss MM",
            "date": "2000",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10829039",
                    "url": "https://glygen.org/publication/PubMed/10829039"
                }
            ],
            "evidence": [
                {
                    "id": "AN6660-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6661-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
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        }
    ]
}