{
    "biomarker_id": "AN6653-1",
    "biomarker_canonical_id": "AN6653",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "increased DPP-4 level",
            "assessed_biomarker_entity_id": "P27487-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Dipeptidyl peptidase 4",
                "synonyms": [
                    {
                        "synonym": "Adenosine deaminase complexing protein 2"
                    },
                    {
                        "synonym": "ADCP-2"
                    },
                    {
                        "synonym": "Dipeptidyl peptidase IV"
                    },
                    {
                        "synonym": "DPP IV"
                    },
                    {
                        "synonym": "ADABP"
                    },
                    {
                        "synonym": "T-cell activation antigen CD26"
                    },
                    {
                        "synonym": "Dipeptidyl peptidase IV soluble form"
                    },
                    {
                        "synonym": "TP103"
                    },
                    {
                        "synonym": "Dipeptidyl peptidase IV membrane form"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6653-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6653-1"
                },
                {
                    "id": "30594915",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30594915",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The serum DPP-IV concentration was measured in 171 male patients with PTC, 81 male patients with a benign thyroid nodule (BTN), and 52 male healthy controls (HCs). he ROC curve indicated a good performance of DPP-IV for discriminating PTC from BTN, with an area under the curve (AUC) of 0.881 (95% CI, 0.840-0.922). Serum DPP-IV demonstrated a modest performance in predicting nonstructurally persistent disease/recurrent disease (NSPRD) survival."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6653-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6653-1"
        },
        {
            "id": "30594915",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30594915",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The serum DPP-IV concentration was measured in 171 male patients with PTC, 81 male patients with a benign thyroid nodule (BTN), and 52 male healthy controls (HCs). he ROC curve indicated a good performance of DPP-IV for discriminating PTC from BTN, with an area under the curve (AUC) of 0.881 (95% CI, 0.840-0.922). Serum DPP-IV demonstrated a modest performance in predicting nonstructurally persistent disease/recurrent disease (NSPRD) survival."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6653-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6653-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma.",
            "journal": "Cancer biomarkers : section A of Disease markers",
            "authors": "Zhang N, Cong X, Zhou D, Guo L, Yuan C, Xu D, Su C",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30594915",
                    "url": "https://glygen.org/publication/PubMed/30594915"
                }
            ],
            "evidence": [
                {
                    "id": "AN6652-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6653-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}