{
    "biomarker_id": "AN6649-1",
    "biomarker_canonical_id": "AN6649",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased VEGF level",
            "assessed_biomarker_entity_id": "O43915-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Vascular endothelial growth factor D",
                "synonyms": [
                    {
                        "synonym": "c-Fos-induced growth factor"
                    },
                    {
                        "synonym": "FIGF"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6649-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6649-1"
                },
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                    "url": "https://glygen.org/publication/PubMed/31254127",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "To further understand the molecular mechanism of PinX1 in renal cancer angiogenesis, we obtained the gene microarray to determine the downstream molecules of PinX1 in renal cancer. Surprisingly, PinX1 promoted the expression level of miR-125a-3p, which is a tumor suppressor of multiple oncogenes, including VEGF, CDK3, FUT5/6, and ERBB2/3."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6649-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6649-1"
        },
        {
            "id": "31254127",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31254127",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "To further understand the molecular mechanism of PinX1 in renal cancer angiogenesis, we obtained the gene microarray to determine the downstream molecules of PinX1 in renal cancer. Surprisingly, PinX1 promoted the expression level of miR-125a-3p, which is a tumor suppressor of multiple oncogenes, including VEGF, CDK3, FUT5/6, and ERBB2/3."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6649-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6649-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.",
            "journal": "Angiogenesis",
            "authors": "Hou P, Li H, Yong H, Chen F, Chu S, Zheng J, Bai J",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31254127",
                    "url": "https://glygen.org/publication/PubMed/31254127"
                }
            ],
            "evidence": [
                {
                    "id": "AN6648-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6649-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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            ],
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                "journal",
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        }
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}