{
    "biomarker_id": "AN6648-1",
    "biomarker_canonical_id": "AN6648",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased PINX1 level",
            "assessed_biomarker_entity_id": "Q96BK5-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "PIN2/TERF1-interacting telomerase inhibitor 1",
                "synonyms": [
                    {
                        "synonym": "TRF1-interacting protein 1"
                    },
                    {
                        "synonym": "Pin2-interacting protein X1"
                    },
                    {
                        "synonym": "Protein 67-11-3"
                    },
                    {
                        "synonym": "Liver-related putative tumor suppressor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6648-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6648-1"
                },
                {
                    "id": "26033551",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26033551",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "PinX1 low expression staining was observed in 7 of 35 (20%) normal renal tissues, and 168 of 278 (60%) ccRCC tissues (P < 0.001) low PinX1 staining correlated with both worse overall and disease-specific survival in ccRCC (P = 0.002 and P = 0.002)."
                        }
                    ]
                },
                {
                    "id": "31254127",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31254127",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "To further understand the molecular mechanism of PinX1 in renal cancer angiogenesis, we obtained the gene microarray to determine the downstream molecules of PinX1 in renal cancer. Surprisingly, PinX1 promoted the expression level of miR-125a-3p, which is a tumor suppressor of multiple oncogenes, including VEGF, CDK3, FUT5/6, and ERBB2/3."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6648-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6648-1"
        },
        {
            "id": "26033551",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26033551",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "PinX1 low expression staining was observed in 7 of 35 (20%) normal renal tissues, and 168 of 278 (60%) ccRCC tissues (P < 0.001) low PinX1 staining correlated with both worse overall and disease-specific survival in ccRCC (P = 0.002 and P = 0.002)."
                }
            ]
        },
        {
            "id": "31254127",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31254127",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "To further understand the molecular mechanism of PinX1 in renal cancer angiogenesis, we obtained the gene microarray to determine the downstream molecules of PinX1 in renal cancer. Surprisingly, PinX1 promoted the expression level of miR-125a-3p, which is a tumor suppressor of multiple oncogenes, including VEGF, CDK3, FUT5/6, and ERBB2/3."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6648-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6648-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-kappaB-dependent transcription.",
            "journal": "Oncotarget",
            "authors": "Li HL, Han L, Chen HR, Meng F, Liu QH, Pan ZQ, Bai J, Zheng JN",
            "date": "2015",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26033551",
                    "url": "https://glygen.org/publication/PubMed/26033551"
                }
            ],
            "evidence": [
                {
                    "id": "AN6647-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6648-1"
                }
            ]
        },
        {
            "title": "PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.",
            "journal": "Angiogenesis",
            "authors": "Hou P, Li H, Yong H, Chen F, Chu S, Zheng J, Bai J",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31254127",
                    "url": "https://glygen.org/publication/PubMed/31254127"
                }
            ],
            "evidence": [
                {
                    "id": "AN6648-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6648-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                }
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            "sort_fields": [
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                "journal",
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}