{
    "biomarker_id": "AN6647-1",
    "biomarker_canonical_id": "AN6647",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "increased PINX1 level",
            "assessed_biomarker_entity_id": "Q96BK5-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "PIN2/TERF1-interacting telomerase inhibitor 1",
                "synonyms": [
                    {
                        "synonym": "TRF1-interacting protein 1"
                    },
                    {
                        "synonym": "Pin2-interacting protein X1"
                    },
                    {
                        "synonym": "Protein 67-11-3"
                    },
                    {
                        "synonym": "Liver-related putative tumor suppressor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "thyroid gland",
                    "namespace": "UBERON",
                    "id": "0002046",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002046",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6647-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6647-1"
                },
                {
                    "id": "30026037",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30026037",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC. PINX1 expression was significantly associated with tumor size, lymph node metastasis, telomerase reverse transcriptase, promoter mutation and recurrence. PINX1 mRNA expression was more pronounced in the recurrent group than in the nonrecurrent group. In addition, results of the binary logistic regression model showed that PINX1 protein expression had a significant influence on recurrence."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6647-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6647-1"
        },
        {
            "id": "30026037",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30026037",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC. PINX1 expression was significantly associated with tumor size, lymph node metastasis, telomerase reverse transcriptase, promoter mutation and recurrence. PINX1 mRNA expression was more pronounced in the recurrent group than in the nonrecurrent group. In addition, results of the binary logistic regression model showed that PINX1 protein expression had a significant influence on recurrence."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6647-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6647-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The clinical significance of PINX1 expression in papillary thyroid carcinoma.",
            "journal": "Human pathology",
            "authors": "Kang J, Han K, Kim HJ, Park JH, Kong JS, Park S, Myung JK",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30026037",
                    "url": "https://glygen.org/publication/PubMed/30026037"
                }
            ],
            "evidence": [
                {
                    "id": "AN6646-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6647-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 1
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            "sort_fields": [
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                "journal",
                "authors",
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}