{
    "biomarker_id": "AN6646-1",
    "biomarker_canonical_id": "AN6646",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "increased SPHK1 level",
            "assessed_biomarker_entity_id": "Q9NYA1-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Sphingosine kinase 1",
                "synonyms": [
                    {
                        "synonym": "Acetyltransferase SPHK1"
                    },
                    {
                        "synonym": "2.3.1.-"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "thyroid gland",
                    "namespace": "UBERON",
                    "id": "0002046",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002046",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6646-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6646-1"
                },
                {
                    "id": "28982849",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28982849",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6646-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6646-1"
        },
        {
            "id": "28982849",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28982849",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6646-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6646-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.",
            "journal": "Anticancer research",
            "authors": "Do SI, Kim HS, Kim K, Lee H, Do IG, Kim DH, Chae SW, Sohn JH",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28982849",
                    "url": "https://glygen.org/publication/PubMed/28982849"
                }
            ],
            "evidence": [
                {
                    "id": "AN6645-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6646-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}