{
    "biomarker_id": "AN6642-1",
    "biomarker_canonical_id": "AN6642",
    "condition": {
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            "resource": "Disease Ontology",
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            "description": "A female reproductive organ cancer that is located_in the ovary."
        },
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                "resource": "Disease Ontology",
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            },
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            },
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                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
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                "name": "ovary neoplasm",
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            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "primary ovarian cancer",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "tumor of the Ovary",
                "description": ""
            },
            {
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
            },
            {
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            },
            {
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                "description": ""
            },
            {
                "id": "MONDO:0008170",
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                "name": "tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
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                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CAP2 level",
            "assessed_biomarker_entity_id": "P40123-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Adenylyl cyclase-associated protein 2",
                "synonyms": []
            },
            "specimen": [
                {
                    "name": "ovary",
                    "namespace": "UBERON",
                    "id": "0000992",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000992",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6642-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6642-1"
                },
                {
                    "id": "32211793",
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                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Multivariate analyses showed that CAP2 expression in ovarian cancer is an independent prognostic factor for recurrence-free survival (P = 0.019). CAP2 expression is upregulated in aggressive histologic types of epithelial ovarian cancer and serves as a novel prognostic biomarker for patient survival."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6642-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6642-1"
        },
        {
            "id": "32211793",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32211793",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Multivariate analyses showed that CAP2 expression in ovarian cancer is an independent prognostic factor for recurrence-free survival (P = 0.019). CAP2 expression is upregulated in aggressive histologic types of epithelial ovarian cancer and serves as a novel prognostic biomarker for patient survival."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6642-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6642-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes.",
            "journal": "Japanese journal of clinical oncology",
            "authors": "Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32211793",
                    "url": "https://glygen.org/publication/PubMed/32211793"
                }
            ],
            "evidence": [
                {
                    "id": "AN6641-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6642-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
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                {
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                    "count": 1
                }
            ],
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                "assessed_biomarker_entity.recommended_name"
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}