{
    "biomarker_id": "AN6641-1",
    "biomarker_canonical_id": "AN6641",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased BTG1 level",
            "assessed_biomarker_entity_id": "P62324-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Protein BTG1",
                "synonyms": [
                    {
                        "synonym": "B-cell translocation gene 1 protein"
                    }
                ]
            },
            "specimen": [],
            "evidence_source": [
                {
                    "id": "AN6641-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6641-1"
                },
                {
                    "id": "25017022",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/25017022",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "We determined the expression and function of B cell translocation gene 1 (BTG1) in thyroid carcinoma. Thyroid samples were obtained from cancer lesions (n=83) and adjacent normal tissue (n=35) in thyroid cancer patients immediately after endoscopic biopsy. TG1 protein expression was significantly lower in thyroid cancer tissue biopsies compared to normal tissue. Reduced BTG1 expression is associated with increased disease severity, suggesting it is a negative regulator of thyroid cancer and can serve as a prognostic indicator."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6641-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6641-1"
        },
        {
            "id": "25017022",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/25017022",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "We determined the expression and function of B cell translocation gene 1 (BTG1) in thyroid carcinoma. Thyroid samples were obtained from cancer lesions (n=83) and adjacent normal tissue (n=35) in thyroid cancer patients immediately after endoscopic biopsy. TG1 protein expression was significantly lower in thyroid cancer tissue biopsies compared to normal tissue. Reduced BTG1 expression is associated with increased disease severity, suggesting it is a negative regulator of thyroid cancer and can serve as a prognostic indicator."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6641-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6641-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "BTG1 expression in thyroid carcinoma: diagnostic indicator and prognostic marker.",
            "journal": "International journal of oncology",
            "authors": "Lu YF, Sun GG, Liu Q, Yang CR, Cheng YJ",
            "date": "2014",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25017022",
                    "url": "https://glygen.org/publication/PubMed/25017022"
                }
            ],
            "evidence": [
                {
                    "id": "AN6639-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6641-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}