{
    "biomarker_id": "AN6630-1",
    "biomarker_canonical_id": "AN6630",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "increased SREBP1 level",
            "assessed_biomarker_entity_id": "P36956-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Sterol regulatory element-binding protein 1",
                "synonyms": [
                    {
                        "synonym": "Class D basic helix-loop-helix protein 1"
                    },
                    {
                        "synonym": "bHLHd1"
                    },
                    {
                        "synonym": "Sterol regulatory element-binding transcription factor 1"
                    },
                    {
                        "synonym": "Transcription factor SREBF1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "thyroid gland",
                    "namespace": "UBERON",
                    "id": "0002046",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002046",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6630-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6630-1"
                },
                {
                    "id": "31887541",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31887541",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The expression of SREBP1 was significantly different among DTCs, thyroid nodules and the adjacent normal tissues. SREBP1 was upregulated follow with the malignancy."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6630-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6630-1"
        },
        {
            "id": "31887541",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31887541",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The expression of SREBP1 was significantly different among DTCs, thyroid nodules and the adjacent normal tissues. SREBP1 was upregulated follow with the malignancy."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6630-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6630-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer.",
            "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
            "authors": "Li C, Peng X, Lv J, Zou H, Liu J, Zhang K, Li Z",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31887541",
                    "url": "https://glygen.org/publication/PubMed/31887541"
                }
            ],
            "evidence": [
                {
                    "id": "AN6627-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6630-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "journal",
                "authors",
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        }
    ]
}