{
    "biomarker_id": "AN6627-1",
    "biomarker_canonical_id": "AN6627",
    "condition": {
        "recommended_name": {
            "id": "DOID:2394",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:2394",
            "name": "ovarian cancer",
            "description": "A female reproductive organ cancer that is located_in the ovary."
        },
        "synonyms": [
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant Ovarian tumor",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "primary ovarian cancer",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "tumor of the Ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased REG4 level",
            "assessed_biomarker_entity_id": "Q9BYZ8-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Regenerating islet-derived protein 4",
                "synonyms": [
                    {
                        "synonym": "Regenerating islet-derived protein IV"
                    },
                    {
                        "synonym": "Reg IV"
                    },
                    {
                        "synonym": "Gastrointestinal secretory protein"
                    },
                    {
                        "synonym": "REG-like protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6627-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6627-1"
                },
                {
                    "id": "26981633",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26981633",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Finally, an ELISA based serum biomarker assay demonstrated increased expression only in patients with mucinous ovarian cancer. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for postoperative follow-up of patients with mucinous ovarian cancer."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6627-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6627-1"
        },
        {
            "id": "26981633",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26981633",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Finally, an ELISA based serum biomarker assay demonstrated increased expression only in patients with mucinous ovarian cancer. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for postoperative follow-up of patients with mucinous ovarian cancer."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6627-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6627-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker.",
            "journal": "PloS one",
            "authors": "Lehtinen L, Vesterkvist P, Roering P, Korpela T, Hattara L, Kaipio K, Mpindi JP, Hynninen J, Auranen A, Davidson B, Haglund C, Iljin K, Grenman S, Siitari H, Carpen O",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26981633",
                    "url": "https://glygen.org/publication/PubMed/26981633"
                }
            ],
            "evidence": [
                {
                    "id": "AN6626-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6627-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}