{
    "biomarker_id": "AN6622-1",
    "biomarker_canonical_id": "AN6622",
    "condition": {
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            "resource": "Disease Ontology",
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            "description": "An organ system cancer that originates in the mammary gland."
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                "name": "breast tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant neoplasm of breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant tumor of the breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast carcinoma",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
    "biomarker_component": [
        {
            "biomarker": "increased TNFRSF11B level",
            "assessed_biomarker_entity_id": "O00300-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Tumor necrosis factor receptor superfamily member 11B",
                "synonyms": [
                    {
                        "synonym": "Osteoprotegerin"
                    },
                    {
                        "synonym": "Osteoclastogenesis inhibitory factor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6622-1"
                },
                {
                    "id": "30348163",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30348163",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Especially in women with ER+ disease, higher circulating OPG concentrations were associated with higher risk of breast cancer-specific. High pre-diagnosis endogenous concentrations of OPG, the decoy receptor for RANKL, were associated with increased risk of death after a breast cancer diagnosis, especially in those with ER+ disease."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "risk"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6622-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6622-1"
        },
        {
            "id": "30348163",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30348163",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Especially in women with ER+ disease, higher circulating OPG concentrations were associated with higher risk of breast cancer-specific. High pre-diagnosis endogenous concentrations of OPG, the decoy receptor for RANKL, were associated with increased risk of death after a breast cancer diagnosis, especially in those with ER+ disease."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6622-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6622-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort.",
            "journal": "BMC cancer",
            "authors": "Sarink D, Schock H, Johnson T, Chang-Claude J, Overvad K, Olsen A, Tjonneland A, Arveux P, Fournier A, Kvaskoff M, Boeing H, Karakatsani A, Trichopoulou A, La Vecchia C, Masala G, Agnoli C, Panico S, Tumino R, Sacerdote C, van Gils CH, Peeters PHM, Weiderpass E, Agudo A, Rodriguez-Barranco M, Huerta JM, Ardanaz E, Gil L, Kaw KT, Schmidt JA, Dossus L, His M, Aune D, Riboli E, Kaaks R, Fortner RT",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30348163",
                    "url": "https://glygen.org/publication/PubMed/30348163"
                }
            ],
            "evidence": [
                {
                    "id": "AN6777-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6622-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
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                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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}