{
    "biomarker_id": "AN6609-1",
    "biomarker_canonical_id": "AN6609",
    "condition": {
        "recommended_name": {
            "id": "DOID:10283",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:10283",
            "name": "prostate cancer",
            "description": "A male reproductive organ cancer that is located_in the prostate."
        },
        "synonyms": [
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "NGP - new growth of prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "hereditary prostate cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "malignant tumor of the prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate cancer, familial",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "tumor of the prostate",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "HPCX1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "HPCX2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "RNASEL familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "familial prostate cancer caused by mutation in RNASEL",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, type 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "HPC1",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, type 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "HPC8",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, type 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "HPC3",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, type 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "HPC4",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, type 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "HPC5",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, type 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "HPC6",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "HPC7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, type 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "HPC9",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "HPC10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "EHBP1 familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "familial prostate cancer caused by mutation in EHBP1",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, type 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "HPC12",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "MSMB familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "familial prostate cancer caused by mutation in MSMB",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, type 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "HPC13",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "HPC11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "HPC14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "HPC15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0700275",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0700275",
                "name": "prostate cancer, hereditary",
                "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents."
            },
            {
                "id": "MIM:601518",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/601518",
                "name": "Prostate cancer, hereditary, 1",
                "description": "Prostate cancer, hereditary, 1"
            },
            {
                "id": "MIM:610997",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/610997",
                "name": "Prostate cancer, hereditary, 9",
                "description": "Prostate cancer, hereditary, 9"
            },
            {
                "id": "MIM:611868",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611868",
                "name": "Prostate cancer, hereditary, 12",
                "description": "Prostate cancer, hereditary, 12"
            },
            {
                "id": "MIM:611928",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611928",
                "name": "Prostate cancer, hereditary, 13",
                "description": "Prostate cancer, hereditary, 13"
            },
            {
                "id": "MIM:611955",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611955",
                "name": "Prostate cancer, hereditary, 11",
                "description": "Prostate cancer, hereditary, 11"
            },
            {
                "id": "MIM:176807",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/176807",
                "name": "Prostate cancer",
                "description": "Prostate cancer"
            }
        ],
        "id": "DOID:10283"
    },
    "biomarker_component": [
        {
            "biomarker": "increased EZH2 level",
            "assessed_biomarker_entity_id": "Q15910-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Histone-lysine N-methyltransferase EZH2",
                "synonyms": [
                    {
                        "synonym": "ENX-1"
                    },
                    {
                        "synonym": "Enhancer of zeste homolog 2"
                    },
                    {
                        "synonym": "Lysine N-methyltransferase 6"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "prostate gland",
                    "namespace": "UBERON",
                    "id": "0002367",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002367",
                    "loinc_code": "96964-2"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6609-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6609-1"
                },
                {
                    "id": "12374981",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/12374981",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "EZH2 protein are increased in metastatic prostate cancer; in addition, clinically localized prostate cancers that express higher concentrations of EZH2 show a poorer prognosis. Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal Progression."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6609-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6609-1"
        },
        {
            "id": "12374981",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/12374981",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "EZH2 protein are increased in metastatic prostate cancer; in addition, clinically localized prostate cancers that express higher concentrations of EZH2 show a poorer prognosis. Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal Progression."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6609-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6609-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The polycomb group protein EZH2 is involved in progression of prostate cancer.",
            "journal": "Nature",
            "authors": "Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM",
            "date": "2002",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12374981",
                    "url": "https://glygen.org/publication/PubMed/12374981"
                }
            ],
            "evidence": [
                {
                    "id": "AN6602-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6609-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
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        },
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            "table_id": "citation",
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}