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    "biomarker_canonical_id": "AN6601",
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                "description": ""
            },
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                "name": "malignant neoplasm of ovary",
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                "id": "MONDO:0008170",
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            },
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                "id": "MONDO:0008170",
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                "description": ""
            },
            {
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                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
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            {
                "id": "MONDO:0008170",
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                "description": ""
            },
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            },
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                "description": ""
            },
            {
                "id": "MONDO:0008170",
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                "description": ""
            },
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                "name": "ovarian malignant tumour",
                "description": ""
            },
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                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
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                "description": ""
            },
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                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased CLDN4 level",
            "assessed_biomarker_entity_id": "O14493-1",
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                "synonyms": [
                    {
                        "synonym": "Clostridium perfringens enterotoxin receptor"
                    },
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                        "synonym": "CPE-R"
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            },
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "Low MLH1 expression was significantly associated with increased progression-free and overall survival, and a normalisation of CA125 levels after chemotherapy. Additionally, low claudin-4 expression was more frequently found among the group with low MLH1 expression."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
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    ],
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        {
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            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6601-1"
        },
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            "id": "31570444",
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            "url": "https://glygen.org/publication/PubMed/31570444",
            "tags": [
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                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Low MLH1 expression was significantly associated with increased progression-free and overall survival, and a normalisation of CA125 levels after chemotherapy. Additionally, low claudin-4 expression was more frequently found among the group with low MLH1 expression."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6601-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6601-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "MLH1 Is a Prognostic Biomarker for Serous Ovarian Cancer Treated With Platinum- and Taxane-based Chemotherapy.",
            "journal": "Anticancer research",
            "authors": "Kawashima N, Yoshida H, Miwa M, Fujiwara K",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31570444",
                    "url": "https://glygen.org/publication/PubMed/31570444"
                }
            ],
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                    "id": "AN6596-1",
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                    "url": "https://biomarkerkb.org/biomarker/AN6601-1"
                }
            ]
        }
    ],
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}