{
    "biomarker_id": "AN6591-1",
    "biomarker_canonical_id": "AN6591",
    "condition": {
        "recommended_name": {
            "id": "DOID:1324",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1324",
            "name": "lung cancer",
            "description": "A respiratory system cancer that is located_in the lung."
        },
        "synonyms": [
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer",
                "description": "A malignant neoplasm involving the lung."
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "adenocarcinoma of lung, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "cancer of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant neoplasm of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant neoplasm of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumor of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumor of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumour of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumour of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility 1",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "LNCR1",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility 1",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "lung cancer susceptibility 3",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "LNCR3",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "lung cancer susceptibility 3",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "lung cancer susceptibility 4",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "LNCR4",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "lung cancer susceptibility 4",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "lung cancer susceptibility 5",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "LNCR5",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "lung cancer susceptibility 5",
                "description": ""
            },
            {
                "id": "MIM:211980",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/211980",
                "name": "Lung cancer",
                "description": "Lung cancer"
            }
        ],
        "id": "DOID:1324"
    },
    "biomarker_component": [
        {
            "biomarker": "increased WASF1 level",
            "assessed_biomarker_entity_id": "Q92558-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Actin-binding protein WASF1",
                "synonyms": [
                    {
                        "synonym": "Protein WAVE-1"
                    },
                    {
                        "synonym": "Verprolin homology domain-containing protein 1"
                    },
                    {
                        "synonym": "Wiskott-Aldrich syndrome protein family member 1"
                    },
                    {
                        "synonym": "WASP family protein member 1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6591-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6591-1"
                },
                {
                    "id": "30532555",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30532555",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "On the bottom left is the WASF1 module which included MYO5A and WASF1. These two genes both interacted with NCKAP1, CYFIP2, and CYFIP1. In this WASF1 module, four genes (CYFIP1, CYFIP2, NCKAP1, and WASF1) were involved in hsa04810: regulation of actin cytoskeleton. It has been reported that actin cytoskeleton was associated with lung cancer migration and invasion"
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6591-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6591-1"
        },
        {
            "id": "30532555",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30532555",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "On the bottom left is the WASF1 module which included MYO5A and WASF1. These two genes both interacted with NCKAP1, CYFIP2, and CYFIP1. In this WASF1 module, four genes (CYFIP1, CYFIP2, NCKAP1, and WASF1) were involved in hsa04810: regulation of actin cytoskeleton. It has been reported that actin cytoskeleton was associated with lung cancer migration and invasion"
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6591-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6591-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.",
            "journal": "OncoTargets and therapy",
            "authors": "Sheng M, Dong Z, Xie Y",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30532555",
                    "url": "https://glygen.org/publication/PubMed/30532555"
                }
            ],
            "evidence": [
                {
                    "id": "AN6590-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6591-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}