{
    "biomarker_id": "AN6588-1",
    "biomarker_canonical_id": "AN6588",
    "condition": {
        "recommended_name": {
            "id": "DOID:10283",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:10283",
            "name": "prostate cancer",
            "description": "A male reproductive organ cancer that is located_in the prostate."
        },
        "synonyms": [
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "NGP - new growth of prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "hereditary prostate cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "malignant tumor of the prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate cancer, familial",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "tumor of the prostate",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "HPCX1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "HPCX2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "RNASEL familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "familial prostate cancer caused by mutation in RNASEL",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, type 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "HPC1",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, type 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "HPC8",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, type 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "HPC3",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, type 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "HPC4",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, type 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "HPC5",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, type 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "HPC6",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "HPC7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, type 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "HPC9",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "HPC10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "EHBP1 familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "familial prostate cancer caused by mutation in EHBP1",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, type 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "HPC12",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "MSMB familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "familial prostate cancer caused by mutation in MSMB",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, type 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "HPC13",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "HPC11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "HPC14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "HPC15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0700275",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0700275",
                "name": "prostate cancer, hereditary",
                "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents."
            },
            {
                "id": "MIM:601518",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/601518",
                "name": "Prostate cancer, hereditary, 1",
                "description": "Prostate cancer, hereditary, 1"
            },
            {
                "id": "MIM:610997",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/610997",
                "name": "Prostate cancer, hereditary, 9",
                "description": "Prostate cancer, hereditary, 9"
            },
            {
                "id": "MIM:611868",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611868",
                "name": "Prostate cancer, hereditary, 12",
                "description": "Prostate cancer, hereditary, 12"
            },
            {
                "id": "MIM:611928",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611928",
                "name": "Prostate cancer, hereditary, 13",
                "description": "Prostate cancer, hereditary, 13"
            },
            {
                "id": "MIM:611955",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611955",
                "name": "Prostate cancer, hereditary, 11",
                "description": "Prostate cancer, hereditary, 11"
            },
            {
                "id": "MIM:176807",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/176807",
                "name": "Prostate cancer",
                "description": "Prostate cancer"
            }
        ],
        "id": "DOID:10283"
    },
    "biomarker_component": [
        {
            "biomarker": "increased FKBP4 level",
            "assessed_biomarker_entity_id": "Q02790-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Peptidyl-prolyl cis-trans isomerase FKBP4",
                "synonyms": [
                    {
                        "synonym": "FK506-binding protein 4"
                    },
                    {
                        "synonym": "FKBP-4"
                    },
                    {
                        "synonym": "51 kDa FK506-binding protein"
                    },
                    {
                        "synonym": "FKBP51"
                    },
                    {
                        "synonym": "59 kDa immunophilin"
                    },
                    {
                        "synonym": "p59"
                    },
                    {
                        "synonym": "HSP-binding immunophilin"
                    },
                    {
                        "synonym": "HBI"
                    },
                    {
                        "synonym": "52 kDa FK506-binding protein"
                    },
                    {
                        "synonym": "52 kDa FKBP"
                    },
                    {
                        "synonym": "FKBP-52"
                    },
                    {
                        "synonym": "FKBP59"
                    },
                    {
                        "synonym": "Rotamase"
                    },
                    {
                        "synonym": "Immunophilin FKBP52"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "prostate gland",
                    "namespace": "UBERON",
                    "id": "0002367",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002367",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6588-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6588-1"
                },
                {
                    "id": "17722004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/17722004",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "FKBP4 was increased in PCa specimen. It was also interesting that FKBP4 (also known as FKBP52) was up-regulated in Pca."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6588-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6588-1"
        },
        {
            "id": "17722004",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/17722004",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "FKBP4 was increased in PCa specimen. It was also interesting that FKBP4 (also known as FKBP52) was up-regulated in Pca."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6588-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6588-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis.",
            "journal": "International journal of cancer",
            "authors": "Lin JF, Xu J, Tian HY, Gao X, Chen QX, Gu Q, Xu GJ, Song JD, Zhao FK",
            "date": "2007",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17722004",
                    "url": "https://glygen.org/publication/PubMed/17722004"
                }
            ],
            "evidence": [
                {
                    "id": "AN6587-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6588-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}