{
    "biomarker_id": "AN6579-1",
    "biomarker_canonical_id": "AN6579",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased AQP1 level",
            "assessed_biomarker_entity_id": "P29972-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Aquaporin-1",
                "synonyms": [
                    {
                        "synonym": "Urine water channel"
                    },
                    {
                        "synonym": "Aquaporin-CHIP"
                    },
                    {
                        "synonym": "Channel-like integral membrane protein of 28 kDa"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "urine",
                    "namespace": "UBERON",
                    "id": "0001088",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001088",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6579-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6579-1"
                },
                {
                    "id": "20375178",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/20375178",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The AQP1 concentrations in patients with either clear cell or papillary carcinoma were significantly greater and clearly separated from those in the nonnephrectomy surgical control patients and the healthy individuals. High concentration of AQP1 in urine demonstrated 100% sensitivity and 100% specificity in detecting renal cancer."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6579-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6579-1"
        },
        {
            "id": "20375178",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/20375178",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The AQP1 concentrations in patients with either clear cell or papillary carcinoma were significantly greater and clearly separated from those in the nonnephrectomy surgical control patients and the healthy individuals. High concentration of AQP1 in urine demonstrated 100% sensitivity and 100% specificity in detecting renal cancer."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6579-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6579-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Urinary biomarkers for the early diagnosis of kidney cancer.",
            "journal": "Mayo Clinic proceedings",
            "authors": "Morrissey JJ, London AN, Luo J, Kharasch ED",
            "date": "2010",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20375178",
                    "url": "https://glygen.org/publication/PubMed/20375178"
                }
            ],
            "evidence": [
                {
                    "id": "AN6578-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6579-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}