{
    "biomarker_id": "AN6569-1",
    "biomarker_canonical_id": "AN6569",
    "condition": {
        "recommended_name": {
            "id": "DOID:2394",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:2394",
            "name": "ovarian cancer",
            "description": "A female reproductive organ cancer that is located_in the ovary."
        },
        "synonyms": [
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant Ovarian tumor",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "primary ovarian cancer",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "tumor of the Ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased VSIG4 level",
            "assessed_biomarker_entity_id": "Q9Y279-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "V-set and immunoglobulin domain-containing protein 4",
                "synonyms": [
                    {
                        "synonym": "Protein Z39Ig"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "ovary",
                    "namespace": "UBERON",
                    "id": "0000992",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000992",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6569-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6569-1"
                },
                {
                    "id": "28498255",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28498255",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "VSIG4 messenger RNA and protein expression levels in ovarian cancer tissues were higher than those in benign ovarian tumors (P = 0.0013 and 0.0001, respectively). Furthermore, soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6569-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6569-1"
        },
        {
            "id": "28498255",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28498255",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "VSIG4 messenger RNA and protein expression levels in ovarian cancer tissues were higher than those in benign ovarian tumors (P = 0.0013 and 0.0001, respectively). Furthermore, soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6569-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6569-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The Significance of VSIG4 Expression in Ovarian Cancer.",
            "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
            "authors": "Byun JM, Jeong DH, Choi IH, Lee DS, Kang MS, Jung KO, Jeon YK, Kim YN, Jung EJ, Lee KB, Sung MS, Kim KT",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28498255",
                    "url": "https://glygen.org/publication/PubMed/28498255"
                }
            ],
            "evidence": [
                {
                    "id": "AN6775-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6569-1"
                }
            ]
        }
    ],
    "section_stats": [
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            "table_id": "biomarker_component",
            "table_stats": [
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                }
            ],
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                "assessed_biomarker_entity_id",
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}