{
    "biomarker_id": "AN6538-1",
    "biomarker_canonical_id": "AN6538",
    "condition": {
        "recommended_name": {
            "id": "DOID:11934",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11934",
            "name": "head and neck cancer",
            "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
        },
        "synonyms": [
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck tumours",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head/neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "tumor of head and neck",
                "description": ""
            }
        ],
        "id": "DOID:11934"
    },
    "biomarker_component": [
        {
            "biomarker": "increased C1GALT1 level",
            "assessed_biomarker_entity_id": "Q9NS00-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",
                "synonyms": [
                    {
                        "synonym": "Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1"
                    },
                    {
                        "synonym": "Beta-1,3-galactosyltransferase"
                    },
                    {
                        "synonym": "Core 1 beta1,3-galactosyltransferase 1"
                    },
                    {
                        "synonym": "C1GalT1"
                    },
                    {
                        "synonym": "Core 1 beta3-Gal-T1"
                    },
                    {
                        "synonym": "B3Gal-T8"
                    },
                    {
                        "synonym": "Core 1 O-glycan T-synthase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "squamous epithelium",
                    "namespace": "UBERON",
                    "id": "0006914",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0006914",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6538-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6538-1"
                },
                {
                    "id": "29930379",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29930379",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "C1GALT1 expression is upregulated in HNSCC tumors and is associated with adverse clinicopathologic features. Moreover, high C1GALT1 expression predicts poor disease-free and overall survivals. For Kaplan\u201a\u00c4\u00ecMeier analysis, we further classified C1GALT1 scores 0\u201a\u00c4\u00ec1 and scores 2\u201a\u00c4\u00ec3 as low and high expression, respectively. Results showed that high C1GALT1 expression was significantly associated with poor disease-free survival and overall survival."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6538-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6538-1"
        },
        {
            "id": "29930379",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29930379",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "C1GALT1 expression is upregulated in HNSCC tumors and is associated with adverse clinicopathologic features. Moreover, high C1GALT1 expression predicts poor disease-free and overall survivals. For Kaplan\u201a\u00c4\u00ecMeier analysis, we further classified C1GALT1 scores 0\u201a\u00c4\u00ec1 and scores 2\u201a\u00c4\u00ec3 as low and high expression, respectively. Results showed that high C1GALT1 expression was significantly associated with poor disease-free survival and overall survival."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6538-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6538-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.",
            "journal": "Oncogene",
            "authors": "Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ, Huang MC",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29930379",
                    "url": "https://glygen.org/publication/PubMed/29930379"
                }
            ],
            "evidence": [
                {
                    "id": "AN6537-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6538-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}