{
    "biomarker_id": "AN6537-1",
    "biomarker_canonical_id": "AN6537",
    "condition": {
        "recommended_name": {
            "id": "DOID:10283",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:10283",
            "name": "prostate cancer",
            "description": "A male reproductive organ cancer that is located_in the prostate."
        },
        "synonyms": [
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "NGP - new growth of prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "hereditary prostate cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "malignant tumor of the prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate cancer, familial",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "tumor of the prostate",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "HPCX1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "HPCX2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "RNASEL familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "familial prostate cancer caused by mutation in RNASEL",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, type 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "HPC1",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, type 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "HPC8",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, type 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "HPC3",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, type 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "HPC4",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, type 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "HPC5",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, type 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "HPC6",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "HPC7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, type 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "HPC9",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "HPC10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "EHBP1 familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "familial prostate cancer caused by mutation in EHBP1",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, type 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "HPC12",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "MSMB familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "familial prostate cancer caused by mutation in MSMB",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, type 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "HPC13",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "HPC11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "HPC14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "HPC15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0700275",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0700275",
                "name": "prostate cancer, hereditary",
                "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents."
            },
            {
                "id": "MIM:601518",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/601518",
                "name": "Prostate cancer, hereditary, 1",
                "description": "Prostate cancer, hereditary, 1"
            },
            {
                "id": "MIM:610997",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/610997",
                "name": "Prostate cancer, hereditary, 9",
                "description": "Prostate cancer, hereditary, 9"
            },
            {
                "id": "MIM:611868",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611868",
                "name": "Prostate cancer, hereditary, 12",
                "description": "Prostate cancer, hereditary, 12"
            },
            {
                "id": "MIM:611928",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611928",
                "name": "Prostate cancer, hereditary, 13",
                "description": "Prostate cancer, hereditary, 13"
            },
            {
                "id": "MIM:611955",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611955",
                "name": "Prostate cancer, hereditary, 11",
                "description": "Prostate cancer, hereditary, 11"
            },
            {
                "id": "MIM:176807",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/176807",
                "name": "Prostate cancer",
                "description": "Prostate cancer"
            }
        ],
        "id": "DOID:10283"
    },
    "biomarker_component": [
        {
            "biomarker": "increased GOLM1 level",
            "assessed_biomarker_entity_id": "Q8NBJ4-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Golgi membrane protein 1",
                "synonyms": [
                    {
                        "synonym": "Golgi membrane protein GP73"
                    },
                    {
                        "synonym": "Golgi phosphoprotein 2"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "urine",
                    "namespace": "UBERON",
                    "id": "0001088",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001088",
                    "loinc_code": ""
                }
            ],
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                    "evidence_list": [
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                            "evidence": "Our data indicating the up-regulation of GOLM1 expression and its appearance in patients' urine suggest GOLM1 as a potential novel biomarker for clinically localized prostate cancer. our group has shown that increased GOLM1 transcript in urine, along with SPINK1 and PCA3 transcript expression, and TMPRSS2:ERG fusion status were able to predict prostate cancer outcome."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
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            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6537-1"
        },
        {
            "id": "18953438",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/18953438",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Our data indicating the up-regulation of GOLM1 expression and its appearance in patients' urine suggest GOLM1 as a potential novel biomarker for clinically localized prostate cancer. our group has shown that increased GOLM1 transcript in urine, along with SPINK1 and PCA3 transcript expression, and TMPRSS2:ERG fusion status were able to predict prostate cancer outcome."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6537-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6537-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer.",
            "journal": "Neoplasia (New York, N.Y.)",
            "authors": "Varambally S, Laxman B, Mehra R, Cao Q, Dhanasekaran SM, Tomlins SA, Granger J, Vellaichamy A, Sreekumar A, Yu J, Gu W, Shen R, Ghosh D, Wright LM, Kladney RD, Kuefer R, Rubin MA, Fimmel CJ, Chinnaiyan AM",
            "date": "2008",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18953438",
                    "url": "https://glygen.org/publication/PubMed/18953438"
                }
            ],
            "evidence": [
                {
                    "id": "AN6527-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6537-1"
                }
            ]
        }
    ],
    "section_stats": [
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            ],
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}