{
    "biomarker_id": "AN6513-1",
    "biomarker_canonical_id": "AN6513",
    "condition": {
        "recommended_name": {
            "id": "DOID:1793",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1793",
            "name": "pancreatic cancer",
            "description": "An endocrine gland cancer located_in the pancreas."
        },
        "synonyms": [
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreas neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic tumor",
                "description": ""
            }
        ],
        "id": "DOID:1793"
    },
    "biomarker_component": [
        {
            "biomarker": "increased OPN level",
            "assessed_biomarker_entity_id": "P10451-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Osteopontin",
                "synonyms": [
                    {
                        "synonym": "Secreted phosphoprotein 1"
                    },
                    {
                        "synonym": "SPP-1"
                    },
                    {
                        "synonym": "Nephropontin"
                    },
                    {
                        "synonym": "Bone sialoprotein 1"
                    },
                    {
                        "synonym": "Urinary stone protein"
                    },
                    {
                        "synonym": "Uropontin"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6513-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6513-1"
                },
                {
                    "id": "15006928",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15006928",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Serum OPN levels, as measured by ELISA, were elevated in the sera of 50 patients with resectable pancreatic adenocarcinoma compared to 22 healthy control individuals (mean +/- SD for OPN was 482 +/- 170 ng/ml and 204 +/- 65 ng/ml, respectively; P < 0.001). Serum OPN may have utility as a diagnostic marker in patients with pancreatic cancer."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6513-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6513-1"
        },
        {
            "id": "15006928",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15006928",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Serum OPN levels, as measured by ELISA, were elevated in the sera of 50 patients with resectable pancreatic adenocarcinoma compared to 22 healthy control individuals (mean +/- SD for OPN was 482 +/- 170 ng/ml and 204 +/- 65 ng/ml, respectively; P < 0.001). Serum OPN may have utility as a diagnostic marker in patients with pancreatic cancer."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6513-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6513-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma.",
            "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology",
            "authors": "Koopmann J, Fedarko NS, Jain A, Maitra A, Iacobuzio-Donahue C, Rahman A, Hruban RH, Yeo CJ, Goggins M",
            "date": "2004",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15006928",
                    "url": "https://glygen.org/publication/PubMed/15006928"
                }
            ],
            "evidence": [
                {
                    "id": "AN6512-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6513-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}