{
    "biomarker_id": "AN6512-1",
    "biomarker_canonical_id": "AN6512",
    "condition": {
        "recommended_name": {
            "id": "DOID:11054",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11054",
            "name": "urinary bladder cancer",
            "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
        },
        "synonyms": [
            {
                "id": "DOID:11054",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11054",
                "name": "bladder cancer",
                "description": ""
            },
            {
                "id": "DOID:11054",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11054",
                "name": "tumor of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "urinary bladder cancer",
                "description": "A primary or metastatic malignant neoplasm involving the bladder."
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "tumor of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "tumour of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "bladder cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "cancer of urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant bladder neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant bladder tumor",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant bladder tumour",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm of bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm of the urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm of urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm, bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant neoplasm, urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumor of bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumor of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumor of the urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumor of urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumor, urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumour of bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumour of the bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumour of the urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant tumour of urinary bladder",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant urinary bladder neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant urinary bladder tumor",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "malignant urinary bladder tumour",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "urinary bladder cancer",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "urinary bladder malignant neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "urinary bladder malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0001187",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                "name": "urinary bladder malignant tumour",
                "description": ""
            },
            {
                "id": "MIM:109800",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/109800",
                "name": "Bladder cancer",
                "description": "Bladder cancer"
            }
        ],
        "id": "DOID:11054"
    },
    "biomarker_component": [
        {
            "biomarker": "increased A1AT level",
            "assessed_biomarker_entity_id": "P01009-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Alpha-1-antitrypsin",
                "synonyms": [
                    {
                        "synonym": "Serpin A1"
                    },
                    {
                        "synonym": "Alpha-1 protease inhibitor"
                    },
                    {
                        "synonym": "Alpha-1-antiproteinase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "urine",
                    "namespace": "UBERON",
                    "id": "0001088",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001088",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6512-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6512-1"
                },
                {
                    "id": "21459797",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21459797",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Increased levels of urinary A1AT glycoprotein were indicative of the presence of bladder cancer (P < 0.0001) and augmented voided urine cytology results. Application of glycoprotein enrichment provided novel candidates for further investigation as biomarkers for the noninvasive detection of bladder cancer."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6512-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6512-1"
        },
        {
            "id": "21459797",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21459797",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Increased levels of urinary A1AT glycoprotein were indicative of the presence of bladder cancer (P < 0.0001) and augmented voided urine cytology results. Application of glycoprotein enrichment provided novel candidates for further investigation as biomarkers for the noninvasive detection of bladder cancer."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6512-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6512-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Urinary glycoprotein biomarker discovery for bladder cancer detection using LC/MS-MS and label-free quantification.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Yang N, Feng S, Shedden K, Xie X, Liu Y, Rosser CJ, Lubman DM, Goodison S",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21459797",
                    "url": "https://glygen.org/publication/PubMed/21459797"
                }
            ],
            "evidence": [
                {
                    "id": "AN6509-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6512-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}
