{
    "biomarker_id": "AN6509-1",
    "biomarker_canonical_id": "AN6509",
    "condition": {
        "recommended_name": {
            "id": "DOID:1793",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1793",
            "name": "pancreatic cancer",
            "description": "An endocrine gland cancer located_in the pancreas."
        },
        "synonyms": [
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreas neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic tumor",
                "description": ""
            }
        ],
        "id": "DOID:1793"
    },
    "biomarker_component": [
        {
            "biomarker": "increased YAP1 level",
            "assessed_biomarker_entity_id": "P46937-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Transcriptional coactivator YAP1",
                "synonyms": [
                    {
                        "synonym": "Protein yorkie homolog"
                    },
                    {
                        "synonym": "Yes-associated protein YAP65 homolog"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "pancreas",
                    "namespace": "UBERON",
                    "id": "0001264",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001264",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6509-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6509-1"
                },
                {
                    "id": "32054505",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32054505",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Mass spectrometry based proteomics showed that YAP1 is the top upregulated protein in pancreatic cancer tissue when compared to normal controls (log2 fold change 6.4; p = 5E-06). Prognostic analysis of YAP1 demonstrated a significant correlation between mRNA expression level data and reduced overall survival (p = 0.001). In addition, TMA and immunohistochemistry analysis suggested that YAP1 protein expression is an independent predictor of poor overall survival [hazard ratio (HR) 1.870, 95% confidence interval (CI) 1.224\u201a\u00c4\u00ec2.855, p = 0.004], as well as reduced disease-free survival (HR 1.950, 95% CI 1.299\u201a\u00c4\u00ec2.927, p = 0.001). Bioinformatic analyses coupled with in vitro assays indicated that YAP1 is involved in the transcriptional control of target genes, associated with extracellular matrix remodeling, which could be modified by selected substances disrupting the YAP1-TEAD interaction. We demonstrate that YAP1 is an independent prognostic marker associated with recurrence and unfavorable survival in pancreatic cancer. We also show that inhibition of YAP1/TEAD interaction interferes with the expression of AREG, CTGF, CYR61, and MSLN suggesting that YAP1 transcriptional activity may affect the development and persistence of a fibrotic tumor microenvironment. YAP1 is thus considered as a clinically and biologically relevant biomarker derived from pancreatic cancer tissue."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6509-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6509-1"
        },
        {
            "id": "32054505",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32054505",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Mass spectrometry based proteomics showed that YAP1 is the top upregulated protein in pancreatic cancer tissue when compared to normal controls (log2 fold change 6.4; p = 5E-06). Prognostic analysis of YAP1 demonstrated a significant correlation between mRNA expression level data and reduced overall survival (p = 0.001). In addition, TMA and immunohistochemistry analysis suggested that YAP1 protein expression is an independent predictor of poor overall survival [hazard ratio (HR) 1.870, 95% confidence interval (CI) 1.224\u201a\u00c4\u00ec2.855, p = 0.004], as well as reduced disease-free survival (HR 1.950, 95% CI 1.299\u201a\u00c4\u00ec2.927, p = 0.001). Bioinformatic analyses coupled with in vitro assays indicated that YAP1 is involved in the transcriptional control of target genes, associated with extracellular matrix remodeling, which could be modified by selected substances disrupting the YAP1-TEAD interaction. We demonstrate that YAP1 is an independent prognostic marker associated with recurrence and unfavorable survival in pancreatic cancer. We also show that inhibition of YAP1/TEAD interaction interferes with the expression of AREG, CTGF, CYR61, and MSLN suggesting that YAP1 transcriptional activity may affect the development and persistence of a fibrotic tumor microenvironment. YAP1 is thus considered as a clinically and biologically relevant biomarker derived from pancreatic cancer tissue."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6509-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6509-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling.",
            "journal": "Journal of translational medicine",
            "authors": "Zhou Q, Bauden M, Andersson R, Hu D, Marko-Varga G, Xu J, Sasor A, Dai H, Pawlowski K, Said Hilmersson K, Chen X, Ansari D",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32054505",
                    "url": "https://glygen.org/publication/PubMed/32054505"
                }
            ],
            "evidence": [
                {
                    "id": "AN6504-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6509-1"
                }
            ]
        }
    ],
    "section_stats": [
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            "table_id": "biomarker_component",
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                    "field": "total",
                    "count": 1
                }
            ],
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
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}