{
    "biomarker_id": "AN6504-1",
    "biomarker_canonical_id": "AN6504",
    "condition": {
        "recommended_name": {
            "id": "DOID:4159",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:4159",
            "name": "skin cancer",
            "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
        },
        "synonyms": [
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "CA - skin cancer",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "malignant neoplasm of skin",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "melanoma and Non-melanoma skin cancer",
                "description": ""
            }
        ],
        "id": "DOID:4159"
    },
    "biomarker_component": [
        {
            "biomarker": "increased BNIP3L level",
            "assessed_biomarker_entity_id": "O60238-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like",
                "synonyms": [
                    {
                        "synonym": "NIP3-like protein X"
                    },
                    {
                        "synonym": "NIP3L"
                    },
                    {
                        "synonym": "Adenovirus E1B19K-binding protein B5"
                    },
                    {
                        "synonym": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6504-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6504-1"
                },
                {
                    "id": "32620611",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32620611",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "A specific antibody response was raised against an antigen identified as BNIP3L, which correlated with a good prognosis. Medium and high expression of BNIP3L was also linked with longer overall survival. BNIP3L is a candidate prognostic marker of clinical outcome of melanoma patients treated with AGI-101H, and may be considered as a prediction marker for patient survival."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6504-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6504-1"
        },
        {
            "id": "32620611",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32620611",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "A specific antibody response was raised against an antigen identified as BNIP3L, which correlated with a good prognosis. Medium and high expression of BNIP3L was also linked with longer overall survival. BNIP3L is a candidate prognostic marker of clinical outcome of melanoma patients treated with AGI-101H, and may be considered as a prediction marker for patient survival."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6504-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6504-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "BNIP3L Is a New Autophagy Related Prognostic Biomarker for Melanoma Patients Treated With AGI-101H.",
            "journal": "Anticancer research",
            "authors": "Kazimierczak U, Kolenda T, Kowalczyk D, Mackiewicz J, Mackiewicz A",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32620611",
                    "url": "https://glygen.org/publication/PubMed/32620611"
                }
            ],
            "evidence": [
                {
                    "id": "AN6503-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6504-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}